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Titolo:
The structure of mixed monolayer films of DPPC and hexadecanol
Autore:
Lawrie, GA; Gentle, IR; Barnes, GT;
Indirizzi:
Univ Queensland, Dept Chem, Brisbane, Qld 4072, Australia Univ QueenslandBrisbane Qld Australia 4072 Brisbane, Qld 4072, Australia
Titolo Testata:
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
fascicolo: 1-3, volume: 171, anno: 2000,
pagine: 217 - 224
SICI:
0927-7757(20001010)171:1-3<217:TSOMMF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
OCTADECANOL MONOLAYERS; EVAPORATION RESISTANCE;
Keywords:
DPPC; hexadecanol; monolayer; lung surfactant; Brewster angle microscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Barnes, GT Univ Queensland, Dept Chem, Brisbane, Qld 4072, Australia Univ Queensland Brisbane Qld Australia 4072 ld 4072, Australia
Citazione:
G.A. Lawrie et al., "The structure of mixed monolayer films of DPPC and hexadecanol", COLL SURF A, 171(1-3), 2000, pp. 217-224

Abstract

Although dipalmitoyl phosphatidycholine (DPPC) is the primary surface active component of natural lung surfactant (NLS), under physiological conditions it does not adsorb rapidly to the interface or respread efficiently or rapidly after compression beyond film collapse. Other materials must be present to enhance these functions and one synthetic exogenous surfactant used in replacement therapy mixes DPPC with hexadecanol and tyloxapol. In the present study the interactions of DPPC and hexadecanol in spread monolayers have been investigated by film balance measurements, and Brewster angle microscopy. Two phases can be observed when the surface pressure is low and themole fraction of DPPC is high: a condensed phase of hexadecanol with some DPPC and an expanded phase. Increasing surface pressure generates a second condensed phase that is DPPC rich. On further compression the expanded phase disappears and the two condensed phases merge, but miscibility rules indicate that the expanded phases do not mix even though there is no evidence for two phases in the experimental data. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:05:45