Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Serum and urinary prostate-specific antigen and urinary human glandular kallikrein concentrations are significantly increased after testosterone administration in female-to-male transsexuals
Autore:
Obiezu, CV; Giltay, EJ; Magklara, A; Scorilas, A; Gooren, LJG; Yu, H; Howarth, DJC; Diamandis, EP;
Indirizzi:
Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada Mt SinaiHosp Toronto ON Canada M5G 1X5 Med, Toronto, ON M5G 1X5, Canada Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 1L5, Canada Univ Toronto Toronto ON Canada M5G 1L5 obiol, Toronto, ON M5G 1L5, Canada Hosp Vrije Univ, Div Androl, Dept Endocrinol, NL-1007 MB Amsterdam, Netherlands Hosp Vrije Univ Amsterdam Netherlands NL-1007 MB Amsterdam, Netherlands Louisiana State Univ, Med Ctr, Dept Med, Shreveport, LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 ed, Shreveport, LA 71130 USA
Titolo Testata:
CLINICAL CHEMISTRY
fascicolo: 6, volume: 46, anno: 2000,
parte:, 1
pagine: 859 - 862
SICI:
0009-9147(200006)46:6<859:SAUPAA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANDROGEN RECEPTOR; BREAST-CANCER; EXPRESSION; MARKER; WOMEN; FLUID; AXIS; HK2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Diamandis, EP Mt Sinai Hosp, Dept Pathol & Lab Med, 600 Univ Ave, Toronto,ON M5G 1X5, Canada Mt Sinai Hosp 600 Univ Ave Toronto ON Canada M5G 1X5 Canada
Citazione:
C.V. Obiezu et al., "Serum and urinary prostate-specific antigen and urinary human glandular kallikrein concentrations are significantly increased after testosterone administration in female-to-male transsexuals", CLIN CHEM, 46(6), 2000, pp. 859-862

Abstract

Background: The genes that encode prostate-specific antigen (PSA) and human glandular kallikrein (hK2) are up-regulated by androgens and progestins in cultured cells, but no published studies have described the effect of androgen administration in women on serum and urinary PSA or hK2. Methods: We measured serum and urinary PSA and hK2 before, and 4 and 12 months post testosterone treatment by immunofluorometric methods in 32 female-to-male transsexuals. Results: Mean serum PSA increased from 1.1 ng/L to 11.1 ng/L and then to 22 ng/L by 4 and 12 months post treatment, respectively; the corresponding mean values in urine were 17, 1420, and 18130 ng/L, respectively. Serum hK2,another kallikrein closely related to PSA, remained undetectable at the three time points. However, urinary hK2 concentration rose from below the detection limit (<6 ng/L) before treatment to 18 and 179 ng/L, by the 4th and the 12th month of treatment, respectively. All changes were statistically significant (P <0.001) at 4 months. Conclusions: Testosterone administration increases serum and urinary PSA and urinary hK2 in women. These measurements may be useful as indicators of androgenic stimulation in women. (C) 2000 American Association for ClinicalChemistry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:41:05