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Titolo:
Age-related increases in plasma phosphatidylcholine hydroperoxide concentrations in control subjects and patients with hyperlipidemia
Autore:
Kinoshita, M; Oikawa, S; Ayasaka, K; Sekikawa, A; Nagashima, T; Toyota, T; Miyazawa, T;
Indirizzi:
Tohoku Univ, Grad Sch Life Sci & Agr, Biodynam Chem Lab, Aoba Ku, Sendai, Miyagi 9818555, Japan Tohoku Univ Sendai Miyagi Japan 9818555 Ku, Sendai, Miyagi 9818555, Japan Tohoku Univ, Sch Med, Dept Internal Med 3, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan
Titolo Testata:
CLINICAL CHEMISTRY
fascicolo: 6, volume: 46, anno: 2000,
parte:, 1
pagine: 822 - 828
SICI:
0009-9147(200006)46:6<822:AIIPPH>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEIN; CORONARY HEART-DISEASE; HUMAN-BLOOD-PLASMA; SCAVENGER RECEPTOR; LIPID-PEROXIDATION; PHOSPHATIDYLETHANOLAMINE HYDROPEROXIDE; PHOSPHOLIPID HYDROPEROXIDES; CELLS; OXIDATION; CHOLESTEROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Oikawa, S Nippon Med Sch, Dept Internal Med 3, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1130022, Japan Nippon Med Sch 1-1-5 Sendagi Tokyo Japan 1130022 1130022, Japan
Citazione:
M. Kinoshita et al., "Age-related increases in plasma phosphatidylcholine hydroperoxide concentrations in control subjects and patients with hyperlipidemia", CLIN CHEM, 46(6), 2000, pp. 822-828

Abstract

Background The basal lipid peroxide concentration in the plasma of patients with hyperlipidemia may be related to atherosclerosis. Quantitative determination of lipid peroxides in the plasma is an important step in the overall evaluation of the biochemical processes leading to oxidative injury. Unfortunately, the currently available methods for lipid peroxidation lack specificity and sensitivity. Methods: Hyperlipidemic patients (44 males and 50 females), ages 12-82 years (mean +/- SE, 53 +/- 2.3 years for males, 58 +/- 2.0 years for females, and 56 +/- 14 years for total cases), and normolipidemic volunteers (controls, 32 males and 15 females), ages 13-90 years (49 +/- 4 years for males, 65 +/- 4 years for females, and 55 +/- 24 years for total cases), were recruited in the present study. Plasma phosphatidylcholine hydroperoxide (PCOOH)was determined by chemiluminescence-HPLC (CL-HPLC). Results: Plasma PCOOH concentrations increased with age in both controls and hyperlipidemic patients. However, the mean plasma PCOOH concentration inpatients with hyperlipidemia (331 +/- 19 nmol/L; n = 94) was significantly(P <0.001) higher than in the controls (160 +/- 65 nmol/L; n = 47). PlasmaPCOOH concentrations were similar in three hyperlipidemic phenotypes: hypercholesterolemia (IIa), hypertriglyceridemia (IV), and combined hyperlipidemia (IIb). The mean plasma PCOOH in patients with treatment-induced normalized plasma lipids was 202 +/- 17 nmol/L. There was no significant correlation between plasma PCOOH concentration and total cholesterol, triglycerides,or phospholipids in hyperlipidemic patients. For all subjects, there was asignificantly positive correlation between plasma PCOOH and each lipid (total cholesterol, P = 0.0002; triglycerides, P = 0.0137; and phospholipids, P <0.0001). Analysis of fatty acids composition of plasma phosphatidylcholine showed significantly low concentrations of n-6 fatty acids moieties (linoleic acid and arachidonic acid) in patients compared with controls. Conclusions: Our results suggest that an increase in plasma PCOOH in patients with hyperlipidemia may be related to the development and progression of atherosclerosis, particularly in the elderly. Measurement of plasma PCOOHis useful for in vivo evaluation of oxidative stress. (C) 2000 American Association for clinical Chemistry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 11:15:19