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Titolo:
Detection of the tax gene of HTLV-I in labial salivary glands from patients with Sjogren's syndrome and other diseases of the oral cavity
Autore:
Mariette, X; Agbalika, F; Zucker-Franklin, D; Clerc, D; Janin, A; Cherot, P; Brouet, JC;
Indirizzi:
Univ Paris 11, Serv Rhumatol, Hop Bicetre, F-94270 Le Kremlin Bicetre, France Univ Paris 11 Le Kremlin Bicetre France F-94270 Kremlin Bicetre, France Hop St Louis, Serv Immunol Clin, Paris, France Hop St Louis Paris France op St Louis, Serv Immunol Clin, Paris, France Hop St Louis, Lab Bacteriol Virol, Paris, France Hop St Louis Paris France St Louis, Lab Bacteriol Virol, Paris, France Hop St Louis, Lab Anatomopathol, Paris, France Hop St Louis Paris France op St Louis, Lab Anatomopathol, Paris, France NYU Med Ctr, Dept Med, New York, NY 10016 USA NYU Med Ctr New York NY USA10016 d Ctr, Dept Med, New York, NY 10016 USA
Titolo Testata:
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
fascicolo: 3, volume: 18, anno: 2000,
pagine: 341 - 347
SICI:
0392-856X(200005/06)18:3<341:DOTTGO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL LEUKEMIA-VIRUS; MYCOSIS-FUNGOIDES; SEQUENCES; RETROVIRUS; EXPRESSION; DNA; AMPLIFICATION; ANTIBODIES; PREVALENCE; PROVIRUS;
Keywords:
Sjogren's syndrome; retrovirus; HTLV-1; tax gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Mariette, X Univ Paris 11, Serv Rhumatol, Hop Bicetre, 78 Av Gen Leclerc, F-94270 Le Kremlin Bicetre, France Univ Paris 11 78 Av Gen Leclerc Le Kremlin Bicetre France F-94270
Citazione:
X. Mariette et al., "Detection of the tax gene of HTLV-I in labial salivary glands from patients with Sjogren's syndrome and other diseases of the oral cavity", CLIN EXP RH, 18(3), 2000, pp. 341-347

Abstract

ObjectiveTo confirm a possible association between Sjogren's syndrome (SS) and the tax gene of human T lymphotropic virus type I(HTLV-I). MethodsWe studied by PCR labial salivary glands (LSG) from 50 patients with definite SS and from 58 controls including 32 patients with LSG involved by other inflammatory processes and 26 normal LSG. Antibodies to HTLV-I and antibodies to the Tax protein were searched for in serum. ResultsWe detected the tax gene of HTLV-I in LSG from 15/50 (30%) of patients with SS but also in specimens from 9/32 (28%) patients with LSG involved by other inflammatory processes (3/9 graft-versus-host disease, 5/19 extravasated cysts, 1/4 sarcoidosis) and from only 1/26 (4%) normal LSG. A 652 bp region, sequenced in 2 SS patients, was 98 - 98.5% homologous to the canonic sequence of tax HTLV-I. The HTLV-I gag, pol and env genes were never detectedThe serum of the SS patients did not contain antibodies to HTLV-I. Howeveranti-Tax antibodies were detected in the serum of 18/25 (72%) SS patients,10/10 (100%) patients positive for tax DNA in their LSG and 8/15 (53%) patients negative for tax DNA in their LSG. ConclusionOur observations raise the possibility that a very low number of copies ofthe tax gene may be harbored innocuously in cells within the oral cavity in some healthy individuals, but that this gene may play a role as a co-factor in the development of SS or other diseases of oral cavity.

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Documento generato il 02/12/20 alle ore 18:18:06