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Titolo:
QTL influencing blood pressure maps to the region of PPH1 on chromosome 2q31-34 in Old Order Amish
Autore:
Hsueh, WC; Mitchell, BD; Schneider, JL; Wagner, MJ; Bell, CJ; Nanthakumar, E; Shuldiner, AR;
Indirizzi:
SW Fdn Biomed Res, Dept Genet, San Antonio, TX 78245 USA SW Fdn Biomed Res San Antonio TX USA 78245 net, San Antonio, TX 78245 USA Glaxo Wellcome Inc, Res Triangle Pk, NC USA Glaxo Wellcome Inc Res Triangle Pk NC USA e Inc, Res Triangle Pk, NC USA Axys Pharmaceut, La Jolla, CA USA Axys Pharmaceut La Jolla CA USAAxys Pharmaceut, La Jolla, CA USA Univ Maryland, Sch Med, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 nd, Sch Med, Baltimore, MD 21201 USA
Titolo Testata:
CIRCULATION
fascicolo: 24, volume: 101, anno: 2000,
pagine: 2810 - 2816
SICI:
0009-7322(20000620)101:24<2810:QIBPMT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY PULMONARY-HYPERTENSION; QUANTITATIVE TRAIT LOCUS; CONGENIC STRAINS; GENETIC-LINKAGE; GENOME SCAN; LOCALIZATION; ASSOCIATION; POPULATION; RAT; ANGIOTENSINOGEN;
Keywords:
blood pressure; Amish; genetics; hypertension, pulmonary;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Mitchell, BD SW Fdn Biomed Res, Dept Genet, POB 760549, San Antonio, TX 78245 USA SW Fdn Biomed Res POB 760549 San Antonio TX USA 78245 245 USA
Citazione:
W.C. Hsueh et al., "QTL influencing blood pressure maps to the region of PPH1 on chromosome 2q31-34 in Old Order Amish", CIRCULATION, 101(24), 2000, pp. 2810-2816

Abstract

Background-Hypertension is a major risk factor for coronary heart disease,strobe, congestive heart failure, renal insufficiency, and peripheral vascular disease. Although the genetic contribution to variation in blood pressure is well recognized, the specific genes involved are mostly unknown. We carried out a genome-wide scan to identify loci influencing blood pressure in the Old Order Amish population of Lancaster County, Pennsylvania. Methods and Results-Blood pressures were measured in 694 adult participants from families recruited without regard to blood pressure. We performed a quantitative linkage analysis by using 357 microsatellite markers. In multipoint analysis, strong evidence for linkage was observed with both diastolic (lod=3.36; P=0.00004) and to a lesser extent systolic (lod=1.64; P=0.003)blood pressure in the region of chromosome 2q31-34. Peak evidence for linkage occurred at map positions 217 and 221 cM from pter for diastolic and systolic blood pressure, respectively,Conclusions-A gene linked to familial primary pulmonary hypertension has recently been mapped to this same region, suggesting the intriguing hypothesis that other (attenuated) mutations in this same gene may influence variation in systolic and diastolic blood pressure in this population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:43:36