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Titolo:
Association of a t29 -> C polymorphism of the transforming growth factor-beta 1 gene with genetic susceptibility to myocardial infarction in Japanese
Autore:
Yokota, M; Ichihara, S; Lin, TL; Nakashima, N; Yamada, Y;
Indirizzi:
Nagoya Univ, Sch Med, Dept Clin Lab Med, Showa Ku, Nagoya, Aichi 4668560, Japan Nagoya Univ Nagoya Aichi Japan 4668560 a Ku, Nagoya, Aichi 4668560, Japan Nagoya Univ, Sch Med, Dept Internal Med 1, Nagoya, Aichi 4668560, Japan Nagoya Univ Nagoya Aichi Japan 4668560 ed 1, Nagoya, Aichi 4668560, Japan Natl Inst Longev Sci, Dept Geriatr Res, Obu, Japan Natl Inst Longev Sci Obu Japan Longev Sci, Dept Geriatr Res, Obu, Japan
Titolo Testata:
CIRCULATION
fascicolo: 24, volume: 101, anno: 2000,
pagine: 2783 - 2787
SICI:
0009-7322(20000620)101:24<2783:AOAT-C>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; FACTOR-BETA; GROWTH-FACTOR-BETA-1 GENE; HEART-DISEASE; RISK FACTOR; TGF-BETA; WOMEN; EXPRESSION; SEQUENCE; LESIONS;
Keywords:
growth substances; genes; myocardial infarction; coronary disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Yokota, M Nagoya Univ, Sch Med, Dept Clin Lab Med, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668560, Japan Nagoya Univ 65 Tsurumai Cho Nagoya Aichi Japan 4668560 60, Japan
Citazione:
M. Yokota et al., "Association of a t29 -> C polymorphism of the transforming growth factor-beta 1 gene with genetic susceptibility to myocardial infarction in Japanese", CIRCULATION, 101(24), 2000, pp. 2783-2787

Abstract

Background-Transforming growth factor-beta (TGF-beta) is an important regulator of vascular remodeling and is involved in the pathogenesis of atherosclerosis, A T-->C transition at nucleotide 29 of the TGF-beta 1 gene results in a Leu-->Pro substitution at amino acid 10 of the signal peptide. We have now examined a possible association of TCF-beta 1 genotype with myocardial infarction (MI) in a Japanese population. Methods and Results-TGF-beta 1 genotype was determined in 315 Japanese patients (234 men and 81 women) with MI and 591 control subjects (289 men and 302 women). We found that age, body mass index, and incidence of habitual smoking, hypertension, diabetes mellitus, and hypercholesterolemia did not differ between the 2 groups for either men or women. Multivariable logistic regression analysis, however, demonstrated the frequency of the T allele tobe significantly higher in male subjects with MI than in controls (TT + TCversus CC; P<0.0001, odds ratio 3.5, 95% CI 2.0 to 63). In contrast, the Tallele was not associated with the prevalence of MI in women. In both maleMI patients and controls, the serum concentration of TGF-beta 1 was significantly higher in individuals with the CC genotype than in subjects with the TT or TC genotype. Conclusions-Findings suggest that the T allele at nucleotide 29 in the TGF-beta 1 gene is a risk factor for genetic susceptibility to MI, at least inmiddle-aged Japanese men.

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Documento generato il 31/03/20 alle ore 19:30:35