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Titolo:
The neurochemical basis of cognitive deficits induced by brain iron deficiency: Involvement of dopamine-opiate system
Autore:
Youdim, MBH; Yehuda, S;
Indirizzi:
Technion Israel Inst Technol, Fac Med, Eve Topf & Natl Parkinson Fdn US, Ctr Neurodegenerat Dis Res,Dept Pharmacol, Haifa, Israel Technion Israel Inst Technol Haifa Israel Dept Pharmacol, Haifa, Israel Bar Ilan Univ, Dept Psychol, Ramat Gan, Tel Aviv, Israel Bar Ilan Univ Ramat Gan Tel Aviv Israel hol, Ramat Gan, Tel Aviv, Israel
Titolo Testata:
CELLULAR AND MOLECULAR BIOLOGY
fascicolo: 3, volume: 46, anno: 2000,
pagine: 491 - 500
SICI:
0145-5680(200005)46:3<491:TNBOCD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; OXIDATIVE STRESS; IMMUNE-SYSTEM; FATTY-ACIDS; INFANTS; ANEMIA; NUTRITION; MEMORY; OLIGODENDROCYTES; THERMOREGULATION;
Keywords:
iron deficiency; dopamine D2 receptor; behavior; enkaphalins; dynorphin B; pain threshold; striatum;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Youdim, MBH Technion Israel Inst Technol, Fac Med, Eve Topf & Natl Parkinson Fdn US, Ctr Neurodegenerat Dis Res,Dept Pharmacol, Efron St, Haifa, Israel Technion Israel Inst Technol Efron St Haifa Israel a, Israel
Citazione:
M.B.H. Youdim e S. Yehuda, "The neurochemical basis of cognitive deficits induced by brain iron deficiency: Involvement of dopamine-opiate system", CELL MOL B, 46(3), 2000, pp. 491-500

Abstract

Iron is an essential element in maintaining normal structure and functionsof the central nervous system. Dangerous effects of decreases in the bioavalibility of iron in the brain are shown to affect brain biochemistry, neurotransmitters production and function, mainly in the dopamine-opiate systems well as cognitive functions (learning and memory) and a number of physiological variables such motor activity and thermoregulation. Recent research has shown the added complications and deficits that are introduced in the endocrine and the immune system activity. While iron deficiency is not perceived as a life threatening disorder, it is the most prevalent nutritional disorder in the world and a better understanding of the modes and sites of action, can help devise better treatment programs for those who suffer from it.

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Documento generato il 26/01/20 alle ore 00:58:40