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Titolo:
Immunohistochemical staining of GLUT1 in benign, hyperplastic, and malignant endometrial epithelia
Autore:
Wang, BY; Kalir, T; Sabo, E; Sherman, DE; Cohen, C; Burstein, DE;
Indirizzi:
CUNY Mt Sinai Sch Med, Dept Pathol, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 athol, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Obstet Gynecol & Reprod Biol, Div Gynecol Oncol, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 Oncol, New York, NY 10029 USA Mt Sinai Sch Med, Ruttenberg Canc Ctr, New York, NY USA Mt Sinai Sch Med New York NY USA , Ruttenberg Canc Ctr, New York, NY USA Bnai Zion Med Ctr, Dept Pathol, Haifa, Israel Bnai Zion Med Ctr Haifa Israel Zion Med Ctr, Dept Pathol, Haifa, Israel
Titolo Testata:
CANCER
fascicolo: 12, volume: 88, anno: 2000,
pagine: 2774 - 2781
SICI:
0008-543X(20000615)88:12<2774:ISOGIB>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE-TRANSPORTER GLUT1; LATE EVENT; EXPRESSION; CARCINOMA; REPRODUCIBILITY; OVEREXPRESSION; LOCALIZATION; MARKER;
Keywords:
human erythrocyte glucose transporter; endometrial adenocarcinoma; endometrial hyperplasia; endometrium; atypical hyperplasia; immunohistochemistry; GLUT1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Burstein, DE CUNY Mt Sinai Sch Med, Dept Pathol, Box 1194,1 Gustave Levy Pl, New York, NY 10029 USA CUNY Mt Sinai Sch Med Box 1194,1 Gustave Levy Pl New York NY USA 10029
Citazione:
B.Y. Wang et al., "Immunohistochemical staining of GLUT1 in benign, hyperplastic, and malignant endometrial epithelia", CANCER, 88(12), 2000, pp. 2774-2781

Abstract

BACKGROUND. Aberrant expression of the facilitative glucose transporter, GLUT1, is found in a wide spectrum of epithelial malignancies. The current study describes an immunohistochemical study of GLUT1 expression in benign, hyperplastic, and malignant endometrial epithelia. METHODS, One hundred sixteen formalin fixed, paraffin embedded sections ofbenign, hyperplastic, and malignant endometrial epithelium were immunostained with rabbit anti-GLUT1 antibody using the streptavidin-biotin method. RESULTS. Proliferative, secretory, and atrophic endometrium were not stained with GLUT1 antiserum. Rare, minute foci of tubal metaplasia stained positively. Simple and complex endometrial hyperplasias were consistently GLUT1negative. All specimens of atypical hyperplasia had foci that were positive for GLUT1. All endometrial adenocarcinomas were GLUT1 positive. CONCLUSIONS. The results of the current study appear to indicate that 1) aberrant overexpression of GLUT1 is a consistent feature of endometrioid adenocarcinoma; 2) GLUT1 immunostaining may be useful in distinguishing benignhyperplasias from hyperplasias that are associated strongly with malignancy; and 3) some or all cases of atypical hyperplasia may be neoplastic rather than hyperplastic, given the existence of a molecular defect common to this hyperplastic subtype and endometrioid adenocarcinoma. (C) 2000 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:54:13