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Titolo:
Effect of streptozotocin-induced diabetes on NGF, P75(NTR) and TrkA content of prevertebral and paravertebral rat sympathetic ganglia
Autore:
Schmidt, RE; Dorsey, DA; Roth, KA; Parvin, CA; Hounsom, L; Tomlinson, DR;
Indirizzi:
Washington Univ, Sch Med, Dept Pathol, Div Neuropathol, St Louis, MO 63110USA Washington Univ St Louis MO USA 63110 Neuropathol, St Louis, MO 63110USA Univ Manchester, Sch Biol Sci, Div Neurosci, Manchester, Lancs, England Univ Manchester Manchester Lancs England sci, Manchester, Lancs, England
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 867, anno: 2000,
pagine: 149 - 156
SICI:
0006-8993(20000609)867:1-2<149:EOSDON>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; RETROGRADE AXONAL-TRANSPORT; DORSAL-ROOT GANGLIA; ILEAL MESENTERIC NERVES; AUTONOMIC NEUROPATHY; SENSORY NEURONS; FACTOR DEPRIVATION; FACTOR RECEPTOR; EXPRESSION; HYDROXYLASE;
Keywords:
diabetic autonomic neuropathy; neuroaxonal dystrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Schmidt, RE Washington Univ, Sch Med, Dept Pathol, Div Neuropathol, St Louis, MO 63110USA Washington Univ St Louis MO USA 63110 , St Louis, MO 63110USA
Citazione:
R.E. Schmidt et al., "Effect of streptozotocin-induced diabetes on NGF, P75(NTR) and TrkA content of prevertebral and paravertebral rat sympathetic ganglia", BRAIN RES, 867(1-2), 2000, pp. 149-156

Abstract

Diabetic autonomic neuropathy results in significant morbidity and mortality. Both diabetic humans and experimental animals show neuroaxonal dystrophy of autonomic nerve terminals, particularly in the prevertebral superior mesenteric ganglia (SMG) and celiac ganglia (CG) which innervate the hyperplastic/hypertrophic diabetic small intestine. Previously, investigators suggested that disturbances in ganglionic nerve growth factor (NGF) content or transport might play a pathogenetic role in diabetic autonomic pathology. To test this hypothesis, we measured NGF content and NGF receptor expression, p75(NTR) (low affinity neurotrophin receptor) and trkA thigh affinity NGFreceptor), in control and diabetic rat SMG, CG and superior cervical ganglia (SCG). Surprisingly, rather than a decrease, we observed an approximate doubling of NGF content in the diabetic SMG and CG, a result which reflectsincreased NGF content;in the hyperplastic diabetic alimentary tract. No change in NGF content was detected in the diabetic SCG which is relatively spared in experimental diabetic autonomic neuropathy. NGF receptor expressionwas not consistently altered in any of the autonomic ganglia. These observations suggest that increased NGF content in sympathetic ganglia innervating the diabetic alimentary tract coupled with intact receptor expression mayproduce aberrant axonal sprouting and neuroaxonal dystrophy. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 23:15:59