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Titolo:
Estrogen reduces acute striatal dopamine responses in vivo to the neurotoxin MPP+ in female, but not male rats
Autore:
Disshon, KA; Dluzen, DE;
Indirizzi:
NE Ohio Univ, Coll Med, Dept Anat, Rootstown, OH 44272 USA NE Ohio Univ Rootstown OH USA 44272 d, Dept Anat, Rootstown, OH 44272 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 868, anno: 2000,
pagine: 95 - 104
SICI:
0006-8993(20000616)868:1<95:ERASDR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MPTP-INDUCED NEUROTOXICITY; 1-METHYL-4-PHENYLPYRIDINIUM ION; INTRACRANIAL MICRODIALYSIS; SEXUAL DIFFERENCES; CAUDATE-NUCLEUS; BRAIN DOPAMINE; BASAL GANGLIA; C57/B1 MICE; CD-1 MICE; RELEASE;
Keywords:
estradiol; microdialysis; MPTP; neuroprotection; neurotoxicity; nigrostriatal; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Dluzen, DE NE Ohio Univ, Coll Med, Dept Anat, Rootstown, OH 44272 USA NE Ohio Univ Rootstown OH USA 44272 t, Rootstown, OH 44272 USA
Citazione:
K.A. Disshon e D.E. Dluzen, "Estrogen reduces acute striatal dopamine responses in vivo to the neurotoxin MPP+ in female, but not male rats", BRAIN RES, 868(1), 2000, pp. 95-104

Abstract

The effects of in vivo estrogen treatment upon MPP+-induced dopamine (DA) release were determined using in vivo microdialysis in female and male mts. Ovariectomized female rats were implanted or not with an estrogen pellet (0.1 mg, 17 beta estradiol) and subjected to microdialysis 6 days later. After baseline DA release was determined, 5 mM MPP+ was infused through the microdialysis probe for one 20-min interval. Perfusion resumed with normal medium for the duration of the experiment. A significant attenuation of MPP+-induced DA release was obtained in estrogen-treated females. One week later, striatal DA and dihydroxyphenylacetic acid (DOPAC) concentrations were determined for the lesioned and non-lesioned striata of each animal. MPP+ infusion significantly decreased striatal DA concentrations, however, there was no effect of estrogen treatment on striatal DA depletion. This experimentwas repeated using orchidectomized male rats treated with 0, 0.1, or 5 mg estradiol. In contrast to the females, no differences in MPP+-induced DA release were seen among these males, and there was no significant effect of the varying estrogen treatments on striatal DA or DOPAC concentrations. These results demonstrate that in vivo estrogen treatment attenuates MPP+-induced striatal DA release in gonadectomized female, but not male, rats. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:42:51