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Titolo:
Axotomy of the sciatic nerve differentially affects expression of metabotropic glutamate receptor mRNA in adult rat motoneurons
Autore:
Anneser, JMH; Berthele, A; Borasio, GD; Castro-Lopes, JM; Zieglgansberger, W; Tolle, TR;
Indirizzi:
Univ Munich, Klinikum Grosshadern, Dept Neurol, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 Dept Neurol, D-81377 Munich, Germany Max Planck Inst Psychiat, Clin Neuropharmacol, D-80804 Munich, Germany MaxPlanck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany Tech Univ Munich, Dept Neurol, D-81675 Munich, Germany Tech Univ Munich Munich Germany D-81675 Neurol, D-81675 Munich, Germany Fac Med Porto, Inst Histol & Embryol, P-4200 Oporto, Portugal Fac Med Porto Oporto Portugal P-4200 & Embryol, P-4200 Oporto, Portugal
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 868, anno: 2000,
pagine: 215 - 221
SICI:
0006-8993(20000623)868:2<215:AOTSND>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; CEREBELLAR GRANULE CELLS; SPINAL-CORD MOTONEURONS; MESSENGER-RNA; MOTOR-NEURONS; IN-VITRO; C-JUN; NMDA; ACTIVATION; IMMUNOREACTIVITY;
Keywords:
spinal cord; excitotoxicity; mGluR; sciatic nerve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Anneser, JMH Univ Munich, Klinikum Grosshadern, Dept Neurol, D-81366 Munich, Germany Univ Munich Munich Germany D-81366 D-81366 Munich, Germany
Citazione:
J.M.H. Anneser et al., "Axotomy of the sciatic nerve differentially affects expression of metabotropic glutamate receptor mRNA in adult rat motoneurons", BRAIN RES, 868(2), 2000, pp. 215-221

Abstract

Previous studies indicated that axotomy exposes motoneurons to glutamatergic excitotoxic stress and protection from glutamatergic overactivation might be crucial for survival. Depending on the experimental model and the subtype involved, activation of metabotropic glutamate receptors (mGluRs) may either enhance excitotoxicity or exert protective effects. To investigate a possible involvement of mGluRs in neuronal rescue mechanisms after axotomy we have monitored the distribution of mGluR mRNA with in situ hybridizationin adult rat motoneurons 1, 2, 3, and 4 weeks after sciatic nerve transection. Motoneurons in sham-operated control animals expressed mGluR 1, 4, and7 mRNA. The mGluR1 mRNA signal was reduced to 49.6+/-6.9% as compared to the contralateral side 2 weeks after axotomy and 31.2+/-8.3% after 4 weeks. The mGluR4 signal declined to 22.1+/-5.1% after 1 week and 10.2+/-1.6% after 2 weeks, remaining stable thereafter. During the entire observation period the mRNA for mGluR7 was not significantly altered. Axotomy did not changethe overall number of motoneurons on the ipsi- or contralateral side. The differential regulation of mGluR subtypes may be part of an adaptive cell program that helps to rescue adult motoneurons from excitotoxic cell death during the stress induced by peripheral denervation. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:14:43