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Titolo:
Promises and challenges of live-attenuated intranasal influenza vaccines across the age spectrum: a review
Autore:
Boyce, TG; Poland, GA;
Indirizzi:
Mayo Med Sch & Fdn, Div Infect Dis, Rochester, MN 55905 USA Mayo Med Sch &Fdn Rochester MN USA 55905 ct Dis, Rochester, MN 55905 USA Mayo Med Sch & Fdn, Dept Pediat & Adolescent Med, Rochester, MN 55905 USA Mayo Med Sch & Fdn Rochester MN USA 55905 nt Med, Rochester, MN 55905 USA Mayo Med Sch & Fdn, Mayo Vaccine Res Grp, Rochester, MN 55905 USA Mayo MedSch & Fdn Rochester MN USA 55905 es Grp, Rochester, MN 55905 USA Mayo Med Sch & Fdn, Clin Pharmacol Unit, Rochester, MN 55905 USA Mayo Med Sch & Fdn Rochester MN USA 55905 l Unit, Rochester, MN 55905 USA
Titolo Testata:
BIOMEDICINE & PHARMACOTHERAPY
fascicolo: 4, volume: 54, anno: 2000,
pagine: 210 - 218
SICI:
0753-3322(200005)54:4<210:PACOLI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
A VIRUS-VACCINES; HEALTH-CARE WORKERS; LONG-TERM-CARE; RANDOMIZED CONTROLLED TRIAL; CHRONICALLY ILL ADULTS; COLD-RECOMBINANT; YOUNG-CHILDREN; ANTIBODY-RESPONSES; ELDERLY PERSONS; WORKING ADULTS;
Keywords:
cold-adapted vaccines; intranasal influenza vaccines; live-attenuated vaccines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Boyce, TG Mayo Med Sch & Fdn, Div Infect Dis, Rochester, MN 55905 USA MayoMed Sch & Fdn Rochester MN USA 55905 chester, MN 55905 USA
Citazione:
T.G. Boyce e G.A. Poland, "Promises and challenges of live-attenuated intranasal influenza vaccines across the age spectrum: a review", BIOMED PHAR, 54(4), 2000, pp. 210-218

Abstract

Despite the availability of inactivated influenza vaccines, influenza continues to cause considerable mortality in the elderly, and morbidity in all age groups. Cold-adapted, live-attenuated, intranasally administered influenza vaccines, first developed in the 1960s, have been tested in more than 10,000 volunteers and have been shown to be safe, well-tolerated, and immunogenic. Recent trials suggest that efficacy in children may be superior to that of inactivated vaccines, and efficacy in healthy adults may be similar to that of inactivated vaccines, although there are limited data comparing the two vaccines directly. Advantages of the live attenuated vaccines include acceptability, ease of administration, and the potential for mass immunization. The possibility of substantially higher vaccination rates across all age groups brings promise for the development of herd immunity and greatly improved control of influenza in the future. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:52:22