Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Insight in the exocytotic process in chromaffin cells: Regulation by trimeric and monomeric G proteins
Autore:
Vitale, N; Gasman, S; Caumont, AS; Gensse, M; Galas, MC; Chasserot-Golaz, S; Bader, MF;
Indirizzi:
INSERM U338, Ctr Neurochim, F-67084 Strasbourg, France INSERM U338 Strasbourg France F-67084 rochim, F-67084 Strasbourg, France
Titolo Testata:
BIOCHIMIE
fascicolo: 4, volume: 82, anno: 2000,
pagine: 365 - 373
SICI:
0300-9084(200004)82:4<365:IITEPI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GTP-BINDING PROTEINS; ANTERIOR-PITUITARY-CELLS; ADP-RIBOSYLATION FACTOR; PHOSPHOLIPASE-D; SECRETORY GRANULES; VESICULAR TRANSPORT; POTENTIAL ROLE; MAST-CELLS; PHOSPHATIDYLINOSITOL 4-KINASE; CATECHOLAMINE SECRETION;
Keywords:
exocytosis; chromaffin cells; G proteins; cytoskeleton; neuroendocrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Bader, MF INSERM U338, Ctr Neurochim, 5 Rue Blaise Pascal, F-67084 Strasbourg, France INSERM U338 5 Rue Blaise Pascal Strasbourg France F-67084 rance
Citazione:
N. Vitale et al., "Insight in the exocytotic process in chromaffin cells: Regulation by trimeric and monomeric G proteins", BIOCHIMIE, 82(4), 2000, pp. 365-373

Abstract

Catecholamine secretion from chromaffin cells has been used for a long time as a general model to study exocytosis of large dense core secretory granules. Permeabilization and microinjection techniques have brought the possibility to dissect at the molecular level the multi-protein machinery involved in this complex physiological process. Regulated exocytosis comprises distinct and sequential steps including the priming of secretory granules, the formation of a docking complex between granules and the plasma membrane and the subsequent fusion of the granule with the plasma membrane. Key proteins involved in the exocytotic machinery have been identified. For instance, SNAREs which participate in the docking events in most intracellular transport steps along the secretory pathway, play a role in exocytosis in both neuronal and endocrine cells. However, in contrast to intracellular transport processes for which the highest fusion efficiency is required after correct targeting of the vesicles, the number of exocytotic events in activatedsecretory cells needs to be tightly controlled. We describe here the multistep control exerted by heterotrimeric and monomeric G proteins on the progression of secretory granules from docking to fusion and the molecular nature of some of their downstream effectors in neuroendocrine chromaffin cells. (C) 2000 societe francaise de biochimie et biologic moleculaire / Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:49:13