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Titolo:
Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids
Autore:
Palmeira, CM; Rana, MI; Frederick, CB; Wallace, KB;
Indirizzi:
Univ Minnesota, Sch Med, Dept Biochem & Mol Biol, Duluth, MN 55812 USA Univ Minnesota Duluth MN USA 55812 ochem & Mol Biol, Duluth, MN 55812 USA Univ Coimbra, Dept Zool, Ctr Neurosci & Cell Biol Coimbra, P-3004517 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3004517 bra, P-3004517 Coimbra, Portugal Rohm & Haas Co, Dept Toxicol, Spring House, PA 19477 USA Rohm & Haas Co Spring House PA USA 19477 icol, Spring House, PA 19477 USA
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 272, anno: 2000,
pagine: 431 - 435
SICI:
0006-291X(20000607)272:2<431:IOTMPT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Keywords:
liver mitochondria; permeability transition; carboxylic acids; cyclosporine A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Wallace, KB Univ Minnesota, Sch Med, Dept Biochem & Mol Biol, Duluth, MN 55812 USA Univ Minnesota Duluth MN USA 55812 Biol, Duluth, MN 55812 USA
Citazione:
C.M. Palmeira et al., "Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids", BIOC BIOP R, 272(2), 2000, pp. 431-435

Abstract

We recently reported that acrylic acid (AA) induces the RIFT in vitro, which we suggested might be a critical event in the acute inflammatory and hyperplastic response of the olfactory epithelium. The purpose of the present investigation was to determine if induction of the MPT is a general response to short-chain carboxylic acids or if there are critical physical chemical parameters for this response. Freshly isolated rat liver mitochondria were incubated in the presence of varying concentrations of selected carboxylic acids. All of the acids that we tested caused a concentration-dependent induction of the MPT, which was blocked by cyclosporine A. Although the C4 carboxylic acids were slightly more potent than the C5 acids, there was no correlation with the degree of saturation, the octanol/water coefficient (log P), or the dissociation constant (pK(a)) of the acids that we tested. We conclude that induction of the MPT in vitro is a general response to short-chain carboxylic acids having a pK(a) of 4 to 5, (C) 2000 Academic Press.

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Documento generato il 05/04/20 alle ore 03:55:13