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Titolo:
L-type calcium channels selectively control the defensive behaviors induced by electrical stimulation of dorsal periaqueductal gray and overlying collicular layers
Autore:
Schenberg, LC; Marcal, LPD; Seeberger, F; de Barros, MR; Sudre, ECM;
Indirizzi:
Fed Univ Espirito Santo, Neurobiol Lab, Ctr Biomed, Dept Physiol Sci, BR-29040090 Vitoria, ES, Brazil Fed Univ Espirito Santo Vitoria ES Brazil BR-29040090 BCtoria, ES, Brazil
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 111, anno: 2000,
pagine: 175 - 185
SICI:
0166-4328(20000615)111:1-2<175:LCCSCT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PONTINE MICTURITION CENTER; AMINO-ACID MICROINJECTION; NUCLEUS-RAPHE-OBSCURUS; SUPERIOR COLLICULUS; PANICOLYTIC DRUGS; 5-HT1A RECEPTORS; CA2+ CHANNELS; NITRIC-OXIDE; GREY-MATTER; IN-VITRO;
Keywords:
L-type calcium channel; periaqueductal gray; PAG; defence reaction; flight behavior; freezing behavior; defensive behavior; logistic threshold analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Schenberg, LC Fed Univ Espirito Santo, Neurobiol Lab, Ctr Biomed, Dept Physiol Sci, Av Marechal Campos 1468 Maruipe, BR-29040090 Vitoria, ES, Brazil Fed Univ Espirito Santo Av Marechal Campos 1468 Maruipe Vitoria ES Brazil BR-29040090 BC
Citazione:
L.C. Schenberg et al., "L-type calcium channels selectively control the defensive behaviors induced by electrical stimulation of dorsal periaqueductal gray and overlying collicular layers", BEH BRA RES, 111(1-2), 2000, pp. 175-185

Abstract

The present study reports the involvement of L-type calcium channels in the control of defensive behaviors produced by electrical stimulation of dorsal periaqueductal gray and overlying collicular layers. Rats that had chemitrodes in the dorsal midbrain and which stimulation produced freezing or flight behaviors with less than 55 mu A were selected for drug experiments. Stimulation was repeated the day after the screening session 20 min following the microinjection into the dorsal periaqueductal gray of 15 nmol of either verapamil, a selective L-type calcium channel antagonist, or cobalt chloride (CoCl2), a calcium-specific channel modulator. Post-drug sessions wereperformed 48 h after. Threshold functions were obtained by logistic fitting of accumulated response frequencies. Verapamil and CoCl2 significantly attenuated the output of immobility, exophthalmus, running and jumping. Although to a lesser degree, verapamil also attenuated defecation. Because CoCl2had no effect on defecation, the attenuation of this response by verapamilsuggests a non-specific action of this drug. Neither verapamil nor CoCl2 changed the output of micturition. Finally, whereas there was a complete recovery of defensive thresholds following the microinjection of verapamil, the attenuating effects of CoCl2 were still present 48 h after. These resultssupport an important role of L-type calcium channels in the neurogenesis of dorsal periaqueductal gray-evoked immobility, exophthalmus, running and jumping, but not defecation and micturition responses. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 16:30:24