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Titolo:
Mismatch negativity in aging and in Alzheimer's and Parkinson's diseases
Autore:
Pekkonen, E;
Indirizzi:
Univ Helsinki, Cent Hosp, Dept Neurol, Helsinki, Finland Univ Helsinki Helsinki Finland ent Hosp, Dept Neurol, Helsinki, Finland Univ Helsinki, Cent Hosp, BioMag Lab, Med Engn Ctr, Helsinki, Finland UnivHelsinki Helsinki Finland Mag Lab, Med Engn Ctr, Helsinki, Finland Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, SF-00100 Helsinki, Finland Univ Helsinki Helsinki Finland SF-00100 Unit, SF-00100 Helsinki, Finland
Titolo Testata:
AUDIOLOGY AND NEURO-OTOLOGY
fascicolo: 3-4, volume: 5, anno: 2000,
pagine: 216 - 224
SICI:
1420-3030(200005/08)5:3-4<216:MNIAAI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; AUDITORY SELECTIVE ATTENTION; INTER-STIMULUS INTERVAL; CLINICAL-APPLICATION; ELDERLY SUBJECTS; SENSORY MEMORY; EEG POTENTIALS; AGE; DEVIANCE; CORTEX;
Keywords:
event-related potential (ERP); mismatch negativity (MMN); memory trace decay; Alzheimer's disease; Parkinson's disease; aging; magnetoencephalography (MEG);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
E. Pekkonen, "Mismatch negativity in aging and in Alzheimer's and Parkinson's diseases", AUDIOL NEUR, 5(3-4), 2000, pp. 216-224

Abstract

Mismatch negativity (MMN) is an auditory event-related potential (ERP) that reflects automatic stimulus discrimination in the human auditory system. By varying the interstimulus intervals (ISIs), the MMN can be used as an index of auditory sensory memory. This paper focuses on MMN findings in agingand in Alzheimer's (AD) and Parkinson's diseases (PD). The accumulated data suggest that MMN to duration deviance, unlike MMN to frequency deviance, is reduced in amplitude in aging at short ISIs. The attenuated MMN to frequency deviance observed at long ISIs in elderly subjects seems to be caused by age-related memory trace decay. Existing results suggest that automatic discrimination for the frequency change is not affected in the early phase of AD, whereas the memory trace seems to decay faster in AD patients. The present findings on PD are not as conclusive, although they tentatively suggest deteriorated automatic change detection. The MMN appears to offer an objective tool for studying auditory processing and memory trace decay in different neurological disorders. Copyright (C) 2000 S. Karger AG, Basel.

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Documento generato il 01/04/20 alle ore 18:04:39