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Titolo:
Maturation of the mismatch negativity: Effects of profound deafness and cochlear implant use
Autore:
Ponton, CW; Eggermont, JJ; Don, M; Waring, MD; Kwong, B; Cunningham, J; Trautwein, P;
Indirizzi:
House Ear Inst, Electrophysiol Lab, Los Angeles, CA 90057 USA House Ear Inst Los Angeles CA USA 90057 ol Lab, Los Angeles, CA 90057 USA House Ear Inst, Childrens Auditory Res & Evaluat Ctr, Los Angeles, CA 90057 USA House Ear Inst Los Angeles CA USA 90057 at Ctr, Los Angeles, CA 90057 USA Northwestern Univ, Auditory Neurosci Lab, Evanston, IL USA Northwestern Univ Evanston IL USA uditory Neurosci Lab, Evanston, IL USA Univ Calgary, Dept Phys & Biophys, Calgary, AB, Canada Univ Calgary Calgary AB Canada Dept Phys & Biophys, Calgary, AB, Canada Univ Calgary, Dept Psychol, Calgary, AB, Canada Univ Calgary Calgary AB Canada algary, Dept Psychol, Calgary, AB, Canada
Titolo Testata:
AUDIOLOGY AND NEURO-OTOLOGY
fascicolo: 3-4, volume: 5, anno: 2000,
pagine: 167 - 185
SICI:
1420-3030(200005/08)5:3-4<167:MOTMNE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; INTRACOCHLEAR ELECTRICAL-STIMULATION; AUDITORY-SYSTEM PLASTICITY; SENSORINEURAL HEARING-LOSS; NEONATALLY DEAFENED CAT; EVOKED MAGNETIC-FIELDS; INTERSTIMULUS-INTERVAL; STIMULUS DEVIANCE; N1 WAVE; CHILDREN;
Keywords:
evoked potentials; auditory cortex; maturation; cochlear implant; deafness; mismatch negativity (MMN);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Ponton, CW House Ear Inst, Electrophysiol Lab, 2100 W 3rd St, Los Angeles,CA 90057 USA House Ear Inst 2100 W 3rd St Los Angeles CA USA 90057 90057 USA
Citazione:
C.W. Ponton et al., "Maturation of the mismatch negativity: Effects of profound deafness and cochlear implant use", AUDIOL NEUR, 5(3-4), 2000, pp. 167-185

Abstract

The use of cochlear implants to restore auditory sensation in deaf children is increasing, with a trend toward earlier implantation. However, little is known about how auditory deprivation and subsequent cochlear implant useaffect the maturing human central auditory system. Our previous studies have demonstrated that the obligatory auditory evoked potentials (AEPs) of implanted children are very different from those of normal-hearing children. Unlike the obligatory potentials, which primarily reflect neural responses to stimulus onset, the mismatch negativity (MMN) provides a neurophysiological measure of auditory short-term memory and discrimination processes. Thepurpose of this investigation is to review our studies of the effects of auditory deprivation due to profound deafness and cochlear implant use on the maturation of the MMN in children, placed in the context of overall age-related changes in the AEPs. The development and application of a statistical technique to assess the MMN in individuals is also reviewed. Results showthat although the morphology of the obligatory AEPs is substantially altered by the absence of a normal N-1 peak, the MMN is robustly present in a group of implanted children who have good spoken language perception through their device. Differences exist in the scalp distribution of the MMN between implanted and normal-hearing children. Specifically, the MMN appears to be more symmetrical in amplitude over both hemispheres, whereas it is initially much larger over the contralateral hemisphere in normal-hearing children. These findings suggest that, compared to N-1, the MMN is a better measure of basic auditory processes necessary for the development of spoken language perception skills in profoundly deaf children and adults who use a cochlear implant. Copyright (C) 2000 S. Karger AG, Basel.

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Documento generato il 19/01/20 alle ore 20:14:12