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Titolo:
Lipoprotein (a) and the risk of ischemic stroke in young women
Autore:
Wityk, RJ; Kittner, SJ; Jenner, JL; Hebel, JR; Epstein, A; Wozniak, MA; Stolley, PD; Stern, BJ; Sloan, MA; Price, TR; McCarter, RJ; Macko, RF; Johnson, CJ; Earley, CJ; Buchholz, DW; Schaefer, EJ;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA Med, Dept Neurol, Baltimore, MD USA Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Dept Neurol, Baltimore, MD 21201 USA Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Prevent Med, Baltimore, MD 21201 USA Tufts Univ, JM USDA Human Nutr Res Ctr Aging, Lipid Metab Lab, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 ing, Lipid Metab Lab, Boston, MA 02111 USA Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 h Med, Dept Neurol, Atlanta, GA 30322 USA
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 2, volume: 150, anno: 2000,
pagine: 389 - 396
SICI:
0021-9150(200006)150:2<389:L(ATRO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; CEREBROVASCULAR-DISEASE; SERUM LIPOPROTEIN(A); APOLIPOPROTEIN(A) PHENOTYPE; MYOCARDIAL-INFARCTION; CEREBRAL INFARCTION; LP(A) LIPOPROTEIN; POTENTIAL ROLE; ATHEROSCLEROSIS; MEN;
Keywords:
ischemic stroke; lipoprotein (a); stroke in the young;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Wityk, RJ Johns Hopkins Hosp, Meyer 5-181B,600 N Wolfe St, Baltimore, MD 21287 USA Johns Hopkins Hosp Meyer 5-181B,600 N Wolfe St Baltimore MD USA 21287
Citazione:
R.J. Wityk et al., "Lipoprotein (a) and the risk of ischemic stroke in young women", ATHEROSCLER, 150(2), 2000, pp. 389-396

Abstract

Background and purpose: lipoprotein (a) (lp (a)) is a lipid-containing particle similar to LDL which has been found in atherosclerotic plaque. The role of lp (a) in ischemic stroke remains controversial, but some studies suggest lp (a) is particularly important as a risk factor for stroke in young adults. We investigated the role of lp (a) as a risk factor for stroke in young women enrolled in the Stroke Prevention in Young Women Study. Methods:subjects were participants in a population-based, case-control study of risk factors for ischemic stroke in young women. Cases were derived from surveillance of 59 regional hospitals in the central Maryland, Washington DC, Pennsylvania and Delaware area. Lp (a) was measured in 110 cases and 216 age-matched controls. Demographics, risk factors, and stroke subtype were determined by interview and review of medical records. Results: lp (a) values were higher in blacks than whites, but within racial groups, the distribution of lp (a) values was similar between cases and controls. After adjustmentfor age, race, hypertension, diabetes, cigarette smoking, coronary artery disease, total cholesterol and HDL cholesterol, the odds ratio for an association of lp (a) and stroke was 1.36 (95% CI 0.80-2.29). There was no dose-response relationship between lp (a) quintile and stroke risk. Among strokesubtypes, only lacunar stroke patients had significantly elevated lp (a) values compared to controls. Conclusions: we found no association of lp (a) with stroke in a population of young women with ischemic stroke. Small numbers of patients limit conclusions regarding risk in ischemic stroke subtypes, but we could not confirm previous suggestions of an association of lp (a) with atherosclerotic stroke in young adults. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:55:16