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Titolo:
Chronic exposure to low-level lead impairs learning ability during aging and energy metabolism in aged rat brain
Autore:
Yun, SW; Lannert, H; Hoyer, S;
Indirizzi:
Univ Heidelberg, Dept Pathochem & Gen Neurochem, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany
Titolo Testata:
ARCHIVES OF GERONTOLOGY AND GERIATRICS
fascicolo: 3, volume: 30, anno: 2000,
pagine: 199 - 213
SICI:
0167-4943(200005/06)30:3<199:CETLLI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; PROTEIN-KINASE-C; NEURONAL PLASTICITY; MEMORY PERFORMANCE; CEREBRAL-CORTEX; ADULT RATS; HIPPOCAMPUS; GLUCOSE; STREPTOZOTOCIN; ISCHEMIA;
Keywords:
aging; brain energy metabolism; lead; learning and memory; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Hoyer, S Univ Heidelberg, Dept Pathochem & Gen Neurochem, Neuenheimer Feld220-221,D-69120 Heidelberg, Germany Univ Heidelberg Neuenheimer Feld 220-221 Heidelberg Germany D-69120
Citazione:
S.W. Yun et al., "Chronic exposure to low-level lead impairs learning ability during aging and energy metabolism in aged rat brain", ARCH GER G, 30(3), 2000, pp. 199-213

Abstract

The neurotoxic effect of chronic exposure to low-level lead (Pb) with advancing age is becoming an important social issue of public health. To examine the effects of low-level Pb treatment on behavior, cognition and brain energy metabolism in aging, we administered 200 ppm Pb acetate to adult (10-month-old) male Wistar rats for 12.5 months. After 12.5 months' exposure, the mean Pb levels in blood and brain had increased to 17.5 mu g/dl and 0.07 mu g/g, respectively, and the rats showed impaired learning and memory functions in a holeboard spatial memory test. No significant difference was found between experimental and control groups in locomotor activity and passive avoidance tests. By HPLC analysis of energy-rich phosphate concentrations, mild abnormalities were found in parietotemporal cortex and hippocampus, but only the 4.4% decrease of ATP in the parietotemporal cortex was statistically significant. These results suggest that chronic exposure to Pb during aging stage may selectively impair learning and memory functions and may cause slight cerebral energy impairment. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 05:58:38