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Titolo:
Necrolytic acral erythema associated with hepatitis C - Effective treatment with interferon alfa and zinc
Autore:
Khanna, VJ; Shieh, S; Benjamin, J; Somach, S; Zaim, MT; Dorner, W; Shill, M; Wood, GS;
Indirizzi:
Case Western Reserve Univ, Univ Hosp Cleveland, Dept Dermatol,Dermatol Serv 11G W, Louis Stokes Cleveland Vet Affairs Med Ctr, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Univ Hosp Cleveland, Dept Internal Med, Louis Stokes Cleveland Vet Affairs Med Ctr, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Univ Hosp Cleveland, Dept Pathol, Louis Stokes Cleveland Vet Affairs Med Ctr, Cleveland, OH 44106 USA Case Western ReserveUniv Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Univ Hosp Cleveland, Dept Gen Med Sci Oncol, Louis Stokes Cleveland Vet Affairs Med Ctr, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Metro Hlth Med Ctr, Dept Dermatol, Cleveland, OH USA Metro Hlth Med Ctr Cleveland OH USA tr, Dept Dermatol, Cleveland, OH USA Akron Gen Med Ctr, Div Gastroenterol, Akron, OH USA Akron Gen Med Ctr Akron OH USA Med Ctr, Div Gastroenterol, Akron, OH USA
Titolo Testata:
ARCHIVES OF DERMATOLOGY
fascicolo: 6, volume: 136, anno: 2000,
pagine: 755 - 757
SICI:
0003-987X(200006)136:6<755:NAEAWH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
3
Recensione:
Indirizzi per estratti:
Indirizzo: Wood, GS Case Western Reserve Univ, Univ Hosp Cleveland, Dept Dermatol,Dermatol Serv 11G W, Louis Stokes Cleveland Vet Affairs Med Ctr, 10701 East Blvd, Cleveland, OH 44106 USA Case Western Reserve Univ 10701 East Blvd Cleveland OH USA 44106
Citazione:
V.J. Khanna et al., "Necrolytic acral erythema associated with hepatitis C - Effective treatment with interferon alfa and zinc", ARCH DERMAT, 136(6), 2000, pp. 755-757

Abstract

Background: Necrolytic acral erythema is a recently described necrolytic erythema that is unique in its exclusive acral location and strong association with hepatitis C. Observation: We report the first case of necrolytic acral erythema in the United States. The patient is a 43-year-old black woman who presented with a 4-year history of tender, flaccid blisters localized to the dorsal aspectof her feet. Serum zinc and glucagon levels were normal. Serum antibodies were positive for hepatitis C, and a liver biopsy specimen showed chronic hepatitis. She was successfully treated with interferon alfa-2b and zinc. Wereview all previously reported cases. Conclusions: Necrolytic acral erythema is a distinct entity. In a review of the literature, most patients were between 35 and 55 years of age, although 1 patient was 12 years old. Five of 8 patients were female. Pour of 7 patients described previously were treated with variable success using oral zinc sulfate and amino acids, whereas 2 were successfully treated with interferon alfa. All patients were infected with hepatitis C. Necrolytic acral erythema appears to be a skin disorder linked to infection with hepatitis C virus that responds to treatment with interferon alfa and oral zinc.

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Documento generato il 03/12/20 alle ore 15:54:00