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Titolo:
The effect of alcohol abuse on the risk of NSAID-related gastrointestinal events
Autore:
Neutel, CI; Appel, WC;
Indirizzi:
Hlth Canada, Therapeut Prod Program, Bur Drug Surveillance, Ottawa, ON, Canada Hlth Canada Ottawa ON Canada , Bur Drug Surveillance, Ottawa, ON, Canada Kusuri Canada Corp, Ottawa, ON, Canada Kusuri Canada Corp Ottawa ON Canada suri Canada Corp, Ottawa, ON, Canada
Titolo Testata:
ANNALS OF EPIDEMIOLOGY
fascicolo: 4, volume: 10, anno: 2000,
pagine: 246 - 250
SICI:
1047-2797(200005)10:4<246:TEOAAO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ANTI-INFLAMMATORY DRUGS; PERFORATION; HEMORRHAGE; TOXICITY; ASPIRIN;
Keywords:
alcohol abuse; NSAIDs; gastrointestinal complications; adverse drug reaction; pharmacoepidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Neutel, CI SCO Hlth Serv, Dept Res, 43 Bruyere St, Ottawa, ON, Canada SCO Hlth Serv 43 Bruyere St Ottawa ON Canada ttawa, ON, Canada
Citazione:
C.I. Neutel e W.C. Appel, "The effect of alcohol abuse on the risk of NSAID-related gastrointestinal events", ANN EPIDEMI, 10(4), 2000, pp. 246-250

Abstract

PURPOSE: Non-steroidal anti-inflammatory drugs (NSAIDs) are known to increase the risk of gastrointestinal (GI) complications. Excessive alcohol consumption may further increase this risk and the FDA is requiring warnings onover-the-counter (OTC) NSAIDs. Our objective is to evaluate the risk of NSAID-related GI events for persons with a history of alcohol abuse. METHODS: This case control study used data from Saskatchewan wan Health. Cases consisted of 1083 patients hospitalized for severe GI events, whereas the control group consisted of 14.754 persons without such hospitalizations. RESULTS: Five percent of cases (n = 54) and 1.9% of controls (n = 273) hada history of treatment for alcohol abuse. The presence of either NSAID useor a history of alcohol abuse led to an odds ratio (OR) of 2.9* for severeGI events, whereas the presence of both risk factors simultaneously led toan OR of 10.2* (additive would be 5.8). Similarly, the presence of ibuprofen and naproxen use, which are OTC in the USA, without alcohol abuse led toan OR of 1.9*, whereas alcohol abuse by itself led to an OR of 2.4*. The presence of both OTC NSAIDs and alcohol abuse simultaneously, led to an OR of 6.5 (additive would be 4.3). Thus with both risk factors present, the resulting risk ratio, is greater than the additive risk of the separate risk factors. CONCLUSIONS: The Food and Drug: Administration (FDA) warning concerns concurrent use of alcohol with NSAIDs, whereas the present study presents the effect of long term alcohol abuse, Further research is needed to separate these two issues to allow physicians to provide the best advice to their patients. *Statistically significant at p < 0.05. (C) 2000 Elsevier Science inc. All rights Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:25:17