Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters
Autore:
Kawabata, K; Hagio, T; Matsumoto, S; Nakao, S; Orita, S; Aze, Y; Ohno, H;
Indirizzi:
Ono Pharmaceut Co Ltd, Minase Res Inst, Osaka 6188585, Japan Ono Pharmaceut Co Ltd Osaka Japan 6188585 Res Inst, Osaka 6188585, Japan Ono Pharmaceut Co Ltd, Fukui Safety Inst, Fukui, Japan Ono Pharmaceut Co Ltd Fukui Japan Ltd, Fukui Safety Inst, Fukui, Japan
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 6, volume: 161, anno: 2000,
pagine: 2013 - 2018
SICI:
1073-449X(200006)161:6<2013:DNEIPS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-LEUKOCYTE ELASTASE; PROTEINASE-INHIBITORS; AWAKE SHEEP; PERMEABILITY; DYSFUNCTION; DEGRADATION; MIGRATION; CARTILAGE; ADHESION; ONO-5046;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kawabata, K Ono Pharmaceut Co Ltd, Minase Res Inst, 3-1-1 Sakurai, Osaka 6188585, Japan Ono Pharmaceut Co Ltd 3-1-1 Sakurai Osaka Japan 6188585 Japan
Citazione:
K. Kawabata et al., "Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters", AM J R CRIT, 161(6), 2000, pp. 2013-2018

Abstract

To define the role of neutrophil elastase (NE) in the progression of acutelung injury (ALI), we examined the effects of post-treatment with a specific NE inhibitor, sivelestat sodium hydrate (sivelestat), on ALI induced by endotoxin (ET) inhalation in hamsters. Inhalation of ET (300 mu g/ml, 30 min) in conscious hamsters increased inflammatory cell count, protein concentration, and hemorrhage in bronchoalveolar lavage fluid (BALF) that peaked 24 h after ET inhalation. These changes were significant 2 h after ET inhalation and paralleled the increase in NE activity in BALF. When intravenouslyinfused from 2 to 24 h post-ET inhalation, sivelestat (0.03 to 3 mg/kg/h) dose-dependently attenuated changes in these BALF parameters at 24 h post-ET inhalation in a manner dependent on the inhibition of NE activity in BALF. Histopathological analysis also indicated that sivelestat prevented the progression of lung inflammation such as alveolar neutrophil infiltration and hemorrhage. In contrast, dexamethasone (3 mg/kg, intravenously) was not effective in this model when administered 2 h after ET inhalation, although it was highly effective when applied before ET. We conclude that delayed inhibition of NE activity with sivelestat prevents subsequent progression of ALI in hamsters after ET inhalation. Thus NE may play an important role in the progression of ALI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:42:53