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Titolo:
Independent inheritance of serum immunoglobulin E concentrations and airway responsiveness
Autore:
Palmer, LJ; Burton, PR; Faux, JA; James, AL; Musk, AW; Cookson, WOCM;
Indirizzi:
Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Leicester, Dept Epidemiol & Publ Hlth, Genet Epidemiol Unit, Leicester, Leics, England Univ Leicester Leicester Leics England l Unit, Leicester, Leics, England John Radcliffe Hosp, Nuffield Dept Clin Med, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Med, Oxford OX3 9DU, England Univ Perth, Dept Med, Dept Pulm Physiol, Perth, WA, Australia Univ Perth Perth WA Australia d, Dept Pulm Physiol, Perth, WA, Australia Sir Charles Gairdiner Hosp, Dept Resp Med, Perth, WA, Australia Sir Charles Gairdiner Hosp Perth WA Australia Med, Perth, WA, Australia TVW Telethon Inst Child Hlth Res, Div Populat Sci, Genet Epidemiol Unit, Perth, WA, Australia TVW Telethon Inst Child Hlth Res Perth WA Australia Perth, WA, Australia
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 6, volume: 161, anno: 2000,
pagine: 1836 - 1843
SICI:
1073-449X(200006)161:6<1836:IIOSIE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN-TEST REACTIVITY; COMMUNITY POPULATION-SAMPLE; BRONCHIAL RESPONSIVENESS; QUANTITATIVE TRAIT; GENERAL-POPULATION; ASTHMA; IGE; PREVALENCE; ATOPY; TWINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Palmer, LJ Harvard Univ, Sch Med, Channing Lab, 181 Longwood Ave, Boston, MA 02115 USA Harvard Univ 181 Longwood Ave Boston MA USA 02115 MA 02115 USA
Citazione:
L.J. Palmer et al., "Independent inheritance of serum immunoglobulin E concentrations and airway responsiveness", AM J R CRIT, 161(6), 2000, pp. 1836-1843

Abstract

Elevated serum Immunoglobulin E (IgE) levels and increased airway responsiveness (AR) are correlated traits that are characteristic of asthma. It is not known to what extent these traits arise from distinct or shared geneticdeterminants. We investigated the genetic and environmental components of variance of serum total and specific IgE levels and AR in an Australian population-based sample of 232 Caucasian nuclear families. The inter-relationships of the genetic determinants of these traits were also investigated. Log, total serum IgE levels had a narrow-sense heritability (h(N)(2)) of 47.3% (SE = 10.0%). Specific serum IgE levels against house dust mite and timothy grass, measured as a RAST Index, ad a h(N)(2) Of 33.8% (SE = 7.3%). AR, quantified by the log, dose-response slope to methacholine (DRS), had a h(N)(2) of 30.0% (SE = 12.3%). Extended modeling demonstrated an approximate 70% overlap in the genetic determinants of total and specific serum IgE levels. The genetic determinants of serum IgE levels and AR exhibited less than30% sharing. These data are consistent with the existence of multiple genetic determinants of the pathophysiologic traits associated with asthma, andsuggest that AR is genetically distinct from atopy. These results have implications for gene discovery programs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 18:20:55