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Titolo:
Absence of an interaction between ibuprofen and zaleplon
Autore:
Garcia, PS; Carcas, A; Zapater, P; Rosendo, J; Paty, I; Leister, CA; Troy, SM;
Indirizzi:
Univ Autonoma Madrid, Fac Med, Hosp La Paz, Serv Farmacol Clin,Dept Pharmacol & Therapeut, Madrid, Spain Univ Autonoma Madrid Madrid Spain Pharmacol & Therapeut, Madrid, Spain Wyeth Ayerst Res, Radnor, PA USA Wyeth Ayerst Res Radnor PA USAWyeth Ayerst Res, Radnor, PA USA
Titolo Testata:
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
fascicolo: 12, volume: 57, anno: 2000,
pagine: 1137 - 1141
SICI:
1079-2082(20000615)57:12<1137:AOAIBI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLEEP DISORDERS; CL-284,846; PREVALENCE; CIMETIDINE; SINGLE;
Keywords:
anti-inflammatory agents; anxiolytics, sedatives and hypnotics; blood levels; drug interactions; excretion; ibuprofen; toxicity; zaleplon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia, PS Autonomous Univ Madrid, Dept Pharmacol & Therapeut, Clin Pharmacol Unit, Avda Arzobispo Morcillo,S-N, Madrid 28029, Spain Autonomous Univ Madrid Avda Arzobispo Morcillo,S-N Madrid Spain 28029
Citazione:
P.S. Garcia et al., "Absence of an interaction between ibuprofen and zaleplon", AM J HEAL S, 57(12), 2000, pp. 1137-1141

Abstract

The potential interaction between zaleplon and ibuprofen was studied. Healthy adult volunteers were given a dose of zaleplon 10 mg alone, a doseof ibuprofen 600 mg alone, or a dose of zaleplon 10 mg and a dose of ibuprofen 600 mg concomitantly in an open-label, randomized, three-period crossover study. There was a seven-day washout period between treatments. Venous blood samples were collected for pharmacokinetic analysis at various intervals up to 14 hours after drug administration. A total of 17 subjects (11 men and 6 women) completed the study. There were no significant differences between zaleplon monotherapy and combination therapy in mean +/- S.D of zaleplon clearance (CL) (2.80 +/- 0.72 versus 2.72 +/- 0.89 L/hr/kg, respectively), maximum plasma concentration (C-max) (3.71 +/- 17.9 versus 39.8 +/- 20.0 ng/mL), or area under the concentration-versus-time curve (AUC) (56.7 +/- 22.8 versus 59.2 +/- 22.0 ng.hr/mL). There were no significant differences between ibuprofen monotherapy and combination therapy in ibuprofen CL (71.6 +/- 17.0 versus 71.7 +/- 14.9 L/hr/kg), C-max (40.8 +/- 10.2 versus 40.4 +/- 10.0 mu g/mL), or Auc (127.6 +/- 29.6 versus 126.4 +/- 29.7 ug.hr/mL). Three subjects had one or more adverse effects with zaleplon alone, one subject had one or more with ibuprofen alone, and one subject had one or more with combination therapy. The adverse effects were mild and resolved without intervention. There was no evidence of a significant interaction between zaleplon and ibuprofen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 21:58:46