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Titolo:
Solid-pseudopapillary tumor of the pancreas: its origin revisited
Autore:
Kosmahl, M; Seada, LS; Janig, U; Harms, D; Kloppel, G;
Indirizzi:
Univ Kiel, Dept Pathol, D-24105 Kiel, Germany Univ Kiel Kiel Germany D-24105 Kiel, Dept Pathol, D-24105 Kiel, Germany Univ Kiel, Dept Pediat Pathol, D-24105 Kiel, Germany Univ Kiel Kiel Germany D-24105 Dept Pediat Pathol, D-24105 Kiel, Germany Benha Fac Med, Cairo, Egypt Benha Fac Med Cairo EgyptBenha Fac Med, Cairo, Egypt
Titolo Testata:
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
fascicolo: 5, volume: 436, anno: 2000,
pagine: 473 - 480
SICI:
0945-6317(200005)436:5<473:STOTPI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAPILLARY-CYSTIC TUMOR; NEURON-SPECIFIC ENOLASE; ACINAR CELL TUMOR; ELECTRON-MICROSCOPY; EPITHELIAL NEOPLASM; DIFFERENTIATION; IMMUNOHISTOCHEMISTRY; ALPHA-1-ANTITRYPSIN; CARCINOMA; MALIGNANCY;
Keywords:
solid-pseudopapillary tumor; immunoprofile; pancreatic origin; genital ridge/ovarian origin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Kloppel, G Univ Kiel, Dept Pathol, Michaelisstr 11, D-24105 Kiel, Germany Univ Kiel Michaelisstr 11 Kiel Germany D-24105 5 Kiel, Germany
Citazione:
M. Kosmahl et al., "Solid-pseudopapillary tumor of the pancreas: its origin revisited", VIRCHOWS AR, 436(5), 2000, pp. 473-480

Abstract

Solid-pseudopapillary tumor of the pancreas (SPT) has distinctive morphologic and biologic features but an unclear origin. It is classified among thepancreatic epithelial tumors, though many are reported to be negative for cytokeratin. Also unclear are its neuroendocrine differentiation, its capability to express alpha-1-antitrypsin (AAT) and, in view of the tumor's striking prevalence in women, its relationship with the female genital tract. To clarify these issues, the immunoprofiles of 59 SPTs were defined by applying a battery of antibodies against cytokeratin, vimentin, neuron-specific enolase (NSE), synaptophysin, chromogranin A, tyrosine hydroxylase (TH), AAT, LeuM1, Ki-MIP, smooth-muscle actin, CD34, alpha-inhibin, calretinin, placental alkaline phosphatase (PLAP), and progesterone and estrogen receptors. The most consistent markers with the strongest immunoreactivity were vimentin, AAT, NSE, and the progesterone receptor, which were each found in more than 90% of the tumors. Using immunocytochemical methods involving antigen retrieval, cytokeratin was demonstrated in almost 70% of the cases. Synaptophysin was found in 22% of the tumors, while chromogranin was absent and tyrosine hydroxylase was only present in a few tumors. None of the other markers tested were expressed by SPTs. This staining pattern fails to reveal a clear phenotypic relationship with any of the defined cell lineages of the pancreas. In view of the striking female preponderance of SPTs and the known close approximation of the genital ridges to the pancreatic anlage during embryogenesis, it is, however, hypothesized that SPTs might derive from genital ridge/ovarian anlage-related cells, which were attached to the pancreatic tissue during early embryogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:08:36