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Titolo:
Adult dogs receiving a rabies booster dose with a recombinant adenovirus expressing rabies virus glycoprotein develop high titers of neutralizing antibodies
Autore:
Tims, T; Briggs, DJ; Davis, RD; Moore, SM; Xiang, ZQ; Ertl, HCJ; Fu, ZF;
Indirizzi:
Kansas State Univ, Coll Vet Med, Dept Diagnost Med Pathobiol, Manhattan, KS 66506 USA Kansas State Univ Manhattan KS USA 66506 thobiol, Manhattan, KS 66506 USA Wistar Inst, Philadelphia, PA 19104 USA Wistar Inst Philadelphia PA USA 19104 ar Inst, Philadelphia, PA 19104 USA
Titolo Testata:
VACCINE
fascicolo: 25, volume: 18, anno: 2000,
pagine: 2804 - 2807
SICI:
0264-410X(20000615)18:25<2804:ADRARB>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
VACCINE;
Keywords:
rabies virus; recombinant adenovirus; virus neutralizing antibody;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Fu, ZF Kansas State Univ, Coll Vet Med, Dept Diagnost Med Pathobiol, 1800 DenisonAve, Manhattan, KS 66506 USA Kansas State Univ 1800 Denison Ave Manhattan KS USA 66506 66506 USA
Citazione:
T. Tims et al., "Adult dogs receiving a rabies booster dose with a recombinant adenovirus expressing rabies virus glycoprotein develop high titers of neutralizing antibodies", VACCINE, 18(25), 2000, pp. 2804-2807

Abstract

Retired greyhound dogs, with low or absent antibody titers to rabies virusfollowing previous vaccinations with commercially available vaccines, wereimmunized either subcutaneously or intramuscularly with a replication-defective recombinant adenovirus expressing the rabies virus glycoprotein termed Adrab.gp. Immunized animals developed high titers (geometric mean titers of 2630 and 5329) of viral neutralizing antibodies (VNA) against rabies virus by 10 days after vaccination. The antibody titers were even higher (geometric mean titers of 19349 and 122086) by 21 days after vaccination. The results indicate that the recombinant adenovirus expressing rabies virus glycoprotein is capable of inducing antibody immune responses in dogs and therefore may be developed as a rabies virus vaccine for dogs. (C) 2000 ElsevierScience Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:18:36