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Titolo:
Macrofilaricidal activity of tetracycline against the filarial nematode Onchocerca ochengi: elimination of Wolbachia precedes worm death and suggestsa dependent relationship
Autore:
Langworthy, NG; Renz, A; Mackenstedt, U; Henkle-Duhrsen, K; Bronsvoort, MBD; Tanya, VN; Donnelly, MJ; Trees, AJ;
Indirizzi:
Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England Univ Liverpool Liverpool Merseyside England L3 5QA A, Merseyside, England Univ Liverpool, Fac Vet Sci, Liverpool L3 5QA, Merseyside, England Univ Liverpool Liverpool Merseyside England L3 5QA A, Merseyside, England Univ Hohenheim, D-70599 Stuttgart, Germany Univ Hohenheim Stuttgart Germany D-70599 eim, D-70599 Stuttgart, Germany Bernhard Nocht Inst Trop Med, D-20359 Hamburg, Germany Bernhard Nocht InstTrop Med Hamburg Germany D-20359 59 Hamburg, Germany Inst Rech Agr Dev, Wakwa, Cameroon Inst Rech Agr Dev Wakwa CameroonInst Rech Agr Dev, Wakwa, Cameroon
Titolo Testata:
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
fascicolo: 1448, volume: 267, anno: 2000,
pagine: 1063 - 1069
SICI:
0962-8452(20000607)267:1448<1063:MAOTAT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACELLULAR BACTERIA; BRUGIA-PAHANGI; IVERMECTIN; VIABILITY; VOLVULUS; CAMEROON; CATTLE;
Keywords:
Onchocerca; Wolbachia; macrofilaricide; tetracycline;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Trees, AJ Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England Univ Liverpool Liverpool Merseyside England L3 5QA ide, England
Citazione:
N.G. Langworthy et al., "Macrofilaricidal activity of tetracycline against the filarial nematode Onchocerca ochengi: elimination of Wolbachia precedes worm death and suggestsa dependent relationship", P ROY SOC B, 267(1448), 2000, pp. 1063-1069

Abstract

Filarial nematodes are important and widespread parasites of animals and humans. We have been using the African bovine parasite Onchocerca ochengi asa chemotherapeutic model for O. volvulus, the causal organism of 'river blindness' in humans, for which there is no safe and effective drug lethal toadult worms. Here we report that the antibiotic, oxytetracycline is macrofilaricidal against O. ochengi. In a controlled trial in Cameroon, all adultworms (as well as microfilariae) were killed, and O. ochengi intradermal nodules resolved, by nine months' post-treatment in cattle treated intermittently for six months. Adult worms removed from concurrent controls remainedfully viable and reproductively active. By serial electron-microscopic examination, the macrofilaricidal effects were related to the elimination of intracellular micro-organisms, initially abundant. Analysis of a fragment ofthe 16S rRNA gene from the O. ochengi micro-organisms confirmed them to beWolbachia organisms of the order Rickettsiales, and showed that the sequence differed in only one nucleotide in 858 from the homologous sequence of the Wolbachia organisms of O. volvulus. These data are, to our knowledge, the first to show that antibiotic therapy can be lethal to adult filariae. They suggest that tetracycline therapy is likely to be macrofilaricidal against O. volvulus infections in humans and, since similar Wolbachia organisms occur in a number of other filarial nematodes, against those infections too. In that the elimination of I Wolbachia preceded the resolution of the filarial infections, they suggest that in O. ochengi at least, the Wolbachia organisms play an essential role in the biology and metabolism of the filarial worm.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:10:38