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Titolo:
Reactive follicular hyperplasia in the lymph node lesions from systemic lupus erythematosus patients: A clinicopathological and immunohistological study of 21 cases
Autore:
Kojima, M; Nakamura, S; Morishita, Y; Itoh, H; Yoshida, K; Ohno, Y; Oyama, T; Asano, S; Joshita, T; Mori, S; Suchi, T; Masawa, N;
Indirizzi:
Dokkyo Univ, Sch Med, Dept Pathol 1, Mibu, Tochigi 3210293, Japan Dokkyo Univ Mibu Tochigi Japan 3210293 ol 1, Mibu, Tochigi 3210293, Japan Aichi Canc Ctr Hosp, Dept Pathol & Clin Labs, Nagoya, Aichi 464, Japan Aichi Canc Ctr Hosp Nagoya Aichi Japan 464 Labs, Nagoya, Aichi 464, Japan Univ Tokyo, Inst Med Sci, Dept Pathol & Oncol, Tokyo, Japan Univ Tokyo Tokyo Japan Inst Med Sci, Dept Pathol & Oncol, Tokyo, Japan Maebashi Res Cross Hosp, Dept Pathol & Clin Labs, Maebashi, Gumma, Japan Maebashi Res Cross Hosp Maebashi Gumma Japan abs, Maebashi, Gumma, Japan Kiryu Welf Gen Hosp, Dept Pathol & Clin Labs, Kiryu, Gumma, Japan Kiryu Welf Gen Hosp Kiryu Gumma Japan l & Clin Labs, Kiryu, Gumma, Japan Tone Cent Hosp, Dept Pathol, Numata, Japan Tone Cent Hosp Numata JapanTone Cent Hosp, Dept Pathol, Numata, Japan Gunma Univ, Sch Med, Dept Pathol 2, Maebashi, Gumma 371, Japan Gunma UnivMaebashi Gumma Japan 371 Pathol 2, Maebashi, Gumma 371, Japan Iwaki Kyoritsu Hosp, Dept Pathol, Iwaki, Fukushima, Japan Iwaki Kyoritsu Hosp Iwaki Fukushima Japan athol, Iwaki, Fukushima, Japan Gunma Univ, Sch Med, Dept Clin Labs, Maebashi, Gumma 371, Japan Gunma Univ Maebashi Gumma Japan 371 Clin Labs, Maebashi, Gumma 371, Japan
Titolo Testata:
PATHOLOGY INTERNATIONAL
fascicolo: 4, volume: 50, anno: 2000,
pagine: 304 - 312
SICI:
1320-5463(200004)50:4<304:RFHITL>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; CASTLEMANS DISEASE; LYMPHOPROLIFERATIVE DISORDER; MORPHOLOGIC FEATURES; RHEUMATOID-ARTHRITIS; KAPOSIS-SARCOMA; INTERLEUKIN-6; LYMPHADENOPATHY; PROTEIN; CELLS;
Keywords:
Castleman's disease; follicular dendritic cell network; follicular hyperplasia; systemic lupus erythematosus; T-zone dysplasia with hyperplastic follicles;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kojima, M Dokkyo Univ, Sch Med, Dept Pathol 1, Mibu, Tochigi 3210293, Japan Dokkyo Univ Mibu Tochigi Japan 3210293 , Tochigi 3210293, Japan
Citazione:
M. Kojima et al., "Reactive follicular hyperplasia in the lymph node lesions from systemic lupus erythematosus patients: A clinicopathological and immunohistological study of 21 cases", PATHOL INT, 50(4), 2000, pp. 304-312

Abstract

To clarify the clinicopathological and immunohistological findings of reactive follicular hyperplasia in systemic lupus erythematosus (SLE) lymphadenopathy, we examined 21 such cases, including four males and 17 females. Three main patterns could be delineated: pattern A, histological features of Castleman's disease (n = 6); pattern B, follicular hyperplasia with pronounced arborizing vasculature in the paracortex resembling T-zone dysplasia with hyperplastic follicles (n = 6); and pattern C, follicular hyperplasia without any other specific findings (n = 9). The patients who showed patterns A and B on histology were all female with a median age of 36 years, and presented with the lymphadenopathy within 4 months, some before a definitive diagnosis could be made. The group with pattern C included four males and five females with an age ranging from 20 to 58 years (mean, 37 years). In seven of them, the lymphadenopathy was noted 6 months or more after the therapy had been initiated. In a virological study, a small to moderate number ofthe lymphoid cells were positive for the Epstein-Barr virus-encoded small RNA in five of 10 cases examined. Human herpesvius 8 was not detected in the four cases examined by polymerase chain reaction and immunohistochemistry. The present study demonstrated that SLE lymphadenopathy showed histological variety and occasionally represented histopathological findings of multicentric Castleman's disease or findings similar to T-zone dysplasia with hyperplastic follicles in the biopsied specimens. We emphasize that careful attention to these morphological features, together with clinical and laboratory examinations, should allow a firm diagnosis of SLE to be made, providing information that is pertinent to the treatment of the disease. Moreover,disarray of the follicular dendritic cell (FDC) network, which could be easily detected by immunohistochemistry, was found in approximately 60% of our series. SLE lymphadenopathy should be listed as one of the diseases occasionally associated with disarray of the FDC network, although its clinicopathological significance remains unclear.

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Documento generato il 29/10/20 alle ore 21:02:44