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Titolo:
REGIONAL VARIATION IN CHOLESTEROL-SYNTHESIS AND LOW-DENSITY-LIPOPROTEIN TRANSPORT IN THE BRAIN OF THE FETUS, NEWBORN AND ADULT ANIMAL
Autore:
TURLEY SD; DIETSCHY JM;
Indirizzi:
UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED DALLAS TX 75235
Titolo Testata:
NMCD. Nutrition Metabolism and Cardiovascular Diseases
fascicolo: 3, volume: 7, anno: 1997,
pagine: 195 - 201
SICI:
0939-4753(1997)7:3<195:RVICAL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEMLI-OPITZ SYNDROME; APOLIPOPROTEIN-E; NERVOUS-SYSTEM; SYNTHESIS INVIVO; LOWERING ACTION; MESSENGER-RNA; WHHL RABBIT; RECEPTOR; TISSUES; HAMSTER;
Keywords:
MYELINATION; CENTRAL NERVOUS SYSTEM; LOW DENSITY LIPOPROTEIN RECEPTOR; SHEEP; HAMSTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
S.D. Turley e J.M. Dietschy, "REGIONAL VARIATION IN CHOLESTEROL-SYNTHESIS AND LOW-DENSITY-LIPOPROTEIN TRANSPORT IN THE BRAIN OF THE FETUS, NEWBORN AND ADULT ANIMAL", NMCD. Nutrition Metabolism and Cardiovascular Diseases, 7(3), 1997, pp. 195-201

Abstract

These studies were designed to characterize the regional differences in cholesterol concentration throughout the brain of the developing sheep and hamster and to learn more about the origin of this cholesterolby measuring in vivo the rates of cholesterol synthesis and low density lipoprotein-cholesterol clearance by different regions of the central nervous system in these animal models. In both species whole brain cholesterol concentration increased several fold throughout fetal and early neonatal life. There were marked regional differences in cholesterol concentration throughout the brain, with the concentration being greatest in the areas richest in myelin. In both hamsters and sheep the differences in cholesterol concentration between the various regionscorrelated strongly with the differences in the rate of cholesterol synthesis. In no region of the central nervous system of the fetal and neonatal sheep could significant rates of LDL transport be detected Together these studies show that cholesterol deposition in the rapidly developing central nervous system of the fetal and neonatal animal doesnot require the uptake of low density lipoprotein-cholesterol from the plasma, but instead appears to be critically dependent on the de novo synthesis of cholesterol within the brain itself. (C)1997, Medikal Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:37:41