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Titolo:
Sildenafil relaxes rabbit clitoral corpus cavernosum
Autore:
Vemulapalli, S; Kurowski, S;
Indirizzi:
Schering Plough Res Inst, CNS, CV Biol Res, Kenilworth, NJ 07033 USA Schering Plough Res Inst Kenilworth NJ USA 07033 Kenilworth, NJ 07033 USA
Titolo Testata:
LIFE SCIENCES
fascicolo: 1, volume: 67, anno: 2000,
pagine: 23 - 29
SICI:
0024-3205(20000526)67:1<23:SRRCCC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALE ERECTILE DYSFUNCTION; NITRIC-OXIDE; SEXUAL DYSFUNCTION; SMOOTH-MUSCLE; PHOSPHODIESTERASE; RELAXATION; NEUROTRANSMISSION; RESPONSES; MEDIATOR; TYPE-5;
Keywords:
sildenafil; clitoris; L-NAME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Vemulapalli, S Schering Plough Res Inst, CNS, CV Biol Res, 2015 Galloping Hill Rd, Kenilworth, NJ 07033 USA Schering Plough Res Inst 2015 Galloping Hill Rd Kenilworth NJ USA 07033
Citazione:
S. Vemulapalli e S. Kurowski, "Sildenafil relaxes rabbit clitoral corpus cavernosum", LIFE SCI, 67(1), 2000, pp. 23-29

Abstract

The role of phosphodiesterase type 5 inhibition in the modulation of female sexual dysfunction was investigated by assessing its effects on in vitro relaxation of rabbit clitoris. Stimulation of the nonadrenergic, non-cholinergic neurons of the clitorus elicited a frequency-dependent relaxation response. inhibition of NO synthase with L-NAME (100 mu M) or inhibition of soluble guanylate cyclase with ODQ (1.0 mu M) almost completely abolished theelectrical field stimulation-induced relaxation of clitorus suggesting that NO-cGMP pathway mediates the relaxation response to electrical field stimulation. Similarly, tetrodotoxin, a neuronal sodium channel blocker abolished the electrical field stimulation-induced clitoral relaxation implying a neuronal release of NO contributes to the electrical field stimulation elicited relaxation. Pretreatment of the clitoral corpus cavernosum strips withsildenafil (100 nM) enhanced the electrical field stimulation-induced relaxations both in magnitude and duration. The results suggest that sildenafilenhances electrical field stimulation elicited clitoral relaxation by a NO-cGMP dependent pathway. These data also imply that sildenafil may be useful to treat female sexual dysfunction, (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 10:21:27