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Titolo:
p53 Gene deletions in paraffin-preserved lymphoid tumors from irradiated mice
Autore:
Paunesku, T; Zhang, YR; Gemmell, MA; Woloschak, GE;
Indirizzi:
Argonne Natl Lab, Biosci Div, Argonne, IL 60439 USA Argonne Natl Lab Argonne IL USA 60439 , Biosci Div, Argonne, IL 60439 USA
Titolo Testata:
LEUKEMIA RESEARCH
fascicolo: 6, volume: 24, anno: 2000,
pagine: 511 - 517
SICI:
0145-2126(200006)24:6<511:PGDIPL>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; LUNG ADENOCARCINOMAS; FISSION NEUTRONS; SUPPRESSOR GENE; MUTANT P53; CELL-LINES; MUTATIONS; MOUSE; ANTIGEN; CANCER;
Keywords:
p53; radiation carcinogenesis; gene deletions; fission-spectrum neutrons; radiation effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Woloschak, GE Argonne Natl Lab, Biosci Div, 9700 S Cass Ave, Argonne, IL 60439 USA Argonne Natl Lab 9700 S Cass Ave Argonne IL USA 60439 39 USA
Citazione:
T. Paunesku et al., "p53 Gene deletions in paraffin-preserved lymphoid tumors from irradiated mice", LEUK RES, 24(6), 2000, pp. 511-517

Abstract

Experiments were performed to measure deletions in the p53 gene in paraffin-embedded tissues (tumors and control) derived from mice exposed to gamma-rays or neutrons up to 28 years ago. Deletions in exons 1, 3, 4, 5, 6, 7 and 9 were monitored by PCR and Southern blotting techniques. The results of these experiments demonstrated p53 deletions in only 1/6 spontaneous tumorsbut in 5/6 gamma-ray-induced and 5/6 neutron-induced tumors. Exons deletedin tumors from gamma-ray exposed mice were similar to those deleted in tumors from neutron-exposed mice. They document differences in spectra of p53 deletions in comparing spontaneous radiation-induced tumors. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:40:05