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Titolo:
Effects of TAK-044, a nonselective endothelin receptor antagonist, on the spontaneous and indomethacin- or methylene blue-induced constriction of theductus arteriosus in rats
Autore:
Takizawa, T; Horikoshi, E; Shen, MH; Masaoka, T; Takagi, H; Yamamoto, M; Kasai, K; Arishima, K;
Indirizzi:
Azabu Univ, Sch Vet Med, Dept Dev Biotechnol, Kanagawa 2298501, Japan Azabu Univ Kanagawa Japan 2298501 ev Biotechnol, Kanagawa 2298501, Japan Azabu Univ, Sch Vet Med, Dept Comparat Toxicol, Kanagawa 2298501, Japan Azabu Univ Kanagawa Japan 2298501 parat Toxicol, Kanagawa 2298501, Japan Azabu Univ, Sch Vet Med, Dept Anat 2, Kanagawa 2298501, Japan Azabu Univ Kanagawa Japan 2298501 , Dept Anat 2, Kanagawa 2298501, Japan Toho Univ, Dept Neurosurg, Meguro Ku, Tokyo 1538515, Japan Toho Univ Tokyo Japan 1538515 Neurosurg, Meguro Ku, Tokyo 1538515, Japan
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 5, volume: 62, anno: 2000,
pagine: 505 - 509
SICI:
0916-7250(200005)62:5<505:EOTANE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; FETAL RATS; LAMB; PROSTAGLANDINS; RELAXATION; INHIBITION; CLOSURE; INACTIVATION; CYCLASE; BIRTH;
Keywords:
ductus arteriosus; endothelin receptor; indomethacin; methylene blue; TAK-044;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Takizawa, T Azabu Univ, Sch Vet Med, Dept Dev Biotechnol, Kanagawa 2298501, Japan Azabu Univ Kanagawa Japan 2298501 l, Kanagawa 2298501, Japan
Citazione:
T. Takizawa et al., "Effects of TAK-044, a nonselective endothelin receptor antagonist, on the spontaneous and indomethacin- or methylene blue-induced constriction of theductus arteriosus in rats", J VET MED S, 62(5), 2000, pp. 505-509

Abstract

We studied the effects of TAK-044, a nonselective endothelin (ET) receptorantagonist, on the indomethacin- or methylene blue-induced constriction ofthe ductus arteriosus (DA) in rats and compared them with the effects on spontaneous DA constriction. Injection of TAK-044 into 21-day-old fetuses inutero was performed through the uterine wall of laparotomized mother rats under light ether anesthesia. The fetuses were autopsied 3 hr after treatment with TAK-044 (10 mg/kg) in utero and simultaneous administration to the laparotomized mother rats of indomethacin (3 mg/kg, po) or methylene blue (100 mg/kg, ip). In the second experiment, pregnant rats were decapitated onday 21 of gestation to obtain newborn rats by cesarean delivery. Newborn rats which were given TAK-044 (2, 10 mg/kg) immediately after or 1 hr beforecesarean delivery were autopsied at various times after birth. In both experiments, pups were rapidly frozen in an acetone-dry ice mixture at autopsyto evaluate the DA constriction by the whole-body freezing and shaving method. TAK-044 injection into the fetus 3 hr before autopsy completely inhibited the DA constriction induced by maternal treatment with indomethacin or methylene blue. TAK-044 caused dose-dependent inhibition of the spontaneousclosure of the DA after birth. The inhibitory effect was more pronounced in pups which were given TAK-044 in utero 1 hr before birth; however, the inhibitory effect was incomplete in newborn pups. These results, together with the previous finding that BQ-123, an ETA-specific receptor antagonist, inhibits the ductal constriction induced by oxygen in vitro [Coceani et al., 1992], indicate that the ETA receptor plays a significant role in the indomethacin- or methylene blue-induced DPI constriction as well as in the spontaneous DA constriction after birth, and also indicate that the inhibition of ETA receptor by TAK-044 was more easily achieved in fetuses than in neonates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:06:20