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Titolo:
Phylogenetic analysis of the cadherin superfamily allows identification ofsix major subfamilies besides several solitary members
Autore:
Nollet, F; Kools, P; van Roy, F;
Indirizzi:
State Univ Ghent, Flanders Interuniv Inst Biotechnol, Dept Mol Biol, Mol Cell Biol Unit, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 l Biol Unit, B-9000 Ghent, Belgium
Titolo Testata:
JOURNAL OF MOLECULAR BIOLOGY
fascicolo: 3, volume: 299, anno: 2000,
pagine: 551 - 572
SICI:
0022-2836(20000609)299:3<551:PAOTCS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; LONG-TERM POTENTIATION; VASCULAR ENDOTHELIAL CADHERIN; MOUSE P-CADHERIN; N-CADHERIN; BETA-CATENIN; R-CADHERIN; H-CADHERIN; CHROMOSOMAL LOCALIZATION; DESMOSOMAL CADHERINS;
Keywords:
cadherins; phylogenetic analysis; genomic organization; protocadherins; structure-function relationships;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
128
Recensione:
Indirizzi per estratti:
Indirizzo: van Roy, F State Univ Ghent, Flanders Interuniv Inst Biotechnol, Dept Mol Biol, Mol Cell Biol Unit, Ledeganckstr 35, B-9000 Ghent, Belgium State UnivGhent Ledeganckstr 35 Ghent Belgium B-9000 Belgium
Citazione:
F. Nollet et al., "Phylogenetic analysis of the cadherin superfamily allows identification ofsix major subfamilies besides several solitary members", J MOL BIOL, 299(3), 2000, pp. 551-572

Abstract

Cadherins play an important role in specific cell-cell adhesion events. Their expression appears to be tightly regulated during development and each tissue or cell type shows a characteristic pattern of cadherin molecules. Inappropriate regulation of their expression levels or functionality has been observed in human malignancies, in many cases leading to aggravated cancer cell invasion and metastasis. The cadherins form a superfamily with at least six subfamilies, which can be distinguished on the basis of protein domain composition, genomic structure, and phylogenetic analysis of the protein sequences. These subfamilies comprise classical or type-I cadherins, atypical or type-II cadherins, desmocollins, desmogleins, protocadherins and Flamingo cadherins. In addition, several cadherins clearly occupy isolated positions in the cadherin superfamily (cadherin-13, -15, -16, -17, Dachsous, RET, FAT, MEGF1 and most invertebrate cadherins). We suggest a different evolutionary origin of the protocadherin and Flamingo cadherin genes versus the genes encoding desmogleins, desmocollins, classical cadherins, and atypical cadherins, The present phylogenetic analysis may accelerate the functional investigation of the whole cadherin superfamily by allowing focused research of prototype cadherins within each subfamily. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 08:34:39