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Titolo:
The PHSRN sequence induces extracellular matrix invasion and accelerates wound healing in obese diabetic mice
Autore:
Livant, DL; Brabec, RK; Kurachi, K; Allen, DL; Wu, YL; Haaseth, R; Andrews, P; Ethier, SP; Markwart, S;
Indirizzi:
Univ Michigan, Sch Med, Dept Dev & Cell Biol, Ann Arbor, MI 48109 USA UnivMichigan Ann Arbor MI USA 48109 & Cell Biol, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Human Genet, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Prot & Carbohydrate Struct Facil, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 truct Facil, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Biochem, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Biochem, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Radiat Oncol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 adiat Oncol, Ann Arbor, MI 48109 USA
Titolo Testata:
JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 11, volume: 105, anno: 2000,
pagine: 1537 - 1545
SICI:
0021-9738(200006)105:11<1537:TPSIEM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-BINDING FRAGMENT; AMINO-ACID-SEQUENCE; GROWTH-FACTOR; FIBROBLAST CHEMOTAXIS; FIBRONECTIN FRAGMENTS; MONOCLONAL-ANTIBODIES; PROVISIONAL MATRIX; SYNTHETIC PEPTIDES; ADHESIVE FUNCTION; TUMOR-CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Livant, DL Univ Michigan, Sch Med, Dept Dev & Cell Biol, 1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan 1150 W Med Ctr Dr Ann Arbor MI USA 48109 8109 USA
Citazione:
D.L. Livant et al., "The PHSRN sequence induces extracellular matrix invasion and accelerates wound healing in obese diabetic mice", J CLIN INV, 105(11), 2000, pp. 1537-1545

Abstract

The PHSRN sequence of the plasma fibronectin (pFn) cell-binding domain induces human keratinocytes and fibroblasts to invade the naturally serum-freeextracellular matricies of sea urchin embryos. The potency of acetylated, amidated PHSRN (Ac-PHSRN-NH2) is significantly increased, making it more active on a molar basis than the 120-kDa cell-binding domain of pFn. Arginineis important to this activity because PHSAN and PHSEN are inactive, as is a randomized sequence peptide, Ac-HSPNR-NH2. One treatment with Ac-PHSRN-NH2 stimulates reepithelialization and contraction of dermal wounds in healing-impaired, obese diabetic C57BL6/KsJ db/db mice. Wound closure is equally rapid in treated db/db and db/+ mice and may be more rapid than in untreated nondiabetic db+ Littermates. In contrast, treatment with either Ac-HSPNR-NH2 or normal saline (NS) has no effect. Analysis of sectioned db/db woundsshows that, in contrast to treatment with Ac-HSPNR-NH2 or NS, a single Ac-PHSRN-NH2 treatment stimulates keratinocyte and fibroblast migration into wounds, enhances fibroplasia and vascularization in the provisional matrix, and stimulates the formation of prominent fibers that may be associated with wound contraction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 07:26:06