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Titolo:
Transient enhancement of GLUT-4 levels in rat epitrochlearis muscle after exercise training
Autore:
Reynolds, TH; Brozinick, JT; Larkin, LM; Cushman, SW;
Indirizzi:
Univ Michigan, Geriatr Ctr, Div Geriatr Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Geriatr Med, Ann Arbor, MI 48109 USA NIDDKD, Expt Diabet Metab & Nutr Sect, Diabet Branch, NIH, Bethesda, MD 20892 USA NIDDKD Bethesda MD USA 20892 , Diabet Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 88, anno: 2000,
pagine: 2240 - 2245
SICI:
8750-7587(200006)88:6<2240:TEOGLI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; GLUCOSE-TRANSPORT CAPACITY; PROTEIN-CONTENT; INSULIN; INCREASES; STIMULATION; CESSATION;
Keywords:
glucose transporters; detraining; glucose metabolism; training cessation; insulin action;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Reynolds, TH Univ Michigan, Geriatr Ctr, Div Geriatr Med, 5131 CCGC,1500 EMed Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan 5131 CCGC,1500 E Med CtrDr Ann Arbor MI USA 48109
Citazione:
T.H. Reynolds et al., "Transient enhancement of GLUT-4 levels in rat epitrochlearis muscle after exercise training", J APP PHYSL, 88(6), 2000, pp. 2240-2245

Abstract

The purpose of the present study was to examine the effect of detraining on the glucose transport system after short-term swim training (5 days), long-term swim training (5 wk), and treadmill run training (5 wk). Skeletal muscles were isolated from female Wistar rats at 24 or 48 h posttraining. SSTproduces a 48% increase in GLUT-4 mRNA, a 30% increase in GLUT-4 protein, and a 60% increase in insulin-stimulated glucose transport activity at 24 hposttraining but not at 48 h posttraining. Similar to SST, long-term swim training produces a 60% increase in GLUT-4 mRNA and a 30% increase in GLUT-4 protein content at 24 h posttraining but not at 48 h posttraining. Finally, treadmill run training produces a transient 35% increase in GLUT-4 protein content that is completely reversed at 48 h after the last bout of exercise. These results demonstrate that the increase in GLUT-4 mRNA and GLUT-4 protein occurs during the first week of exercise training and is rapidly lost after training cessation. We believe that the transient enhancement in GLUT-4 protein after exercise training is due to a short GLUT-4 half-life, aprocess that is primarily regulated by pretranslational mechanisms.

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Documento generato il 10/07/20 alle ore 12:13:34