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Titolo:
Sensory modalities conveyed in the hindlimb somatic afferent input to nucleus tractus solitarius
Autore:
Toney, GM; Mifflin, SW;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Physiol 7756, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 ysiol 7756, San Antonio, TX 78229 USA Univ Texas, Hlth Sci Ctr, Dept Pharmacol, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 Pharmacol, San Antonio, TX 78229 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 88, anno: 2000,
pagine: 2062 - 2073
SICI:
8750-7587(200006)88:6<2062:SMCITH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETICULARIS-DORSALIS NEURONS; TIME-DEPENDENT INHIBITION; MUSCULAR-CONTRACTION; CARDIOVASCULAR-RESPONSES; CAROTID BARORECEPTORS; ANESTHETIZED RATS; SKELETAL-MUSCLE; SPINAL-CORD; MEDULLA; REFLEX;
Keywords:
skeletal muscle; skin; muscle contraction; thermal receptor; exercise;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Toney, GM Univ Texas, Hlth Sci Ctr, Dept Physiol 7756, 7703 Floyd Curl Dr,San Antonio, TX 78229 USA Univ Texas 7703 Floyd Curl Dr San Antonio TX USA78229 78229 USA
Citazione:
G.M. Toney e S.W. Mifflin, "Sensory modalities conveyed in the hindlimb somatic afferent input to nucleus tractus solitarius", J APP PHYSL, 88(6), 2000, pp. 2062-2073

Abstract

To determine the somatic sensory modalities conveyed by hindlimb somatic afferent inputs, the discharge of neurons in the nucleus tractus solitarius was recorded in anesthetized rats after electrical stimulation of either the contralateral sciatic nerve or L-6 spinal nerve, which innervates the hindlimb. The discharge of seven of eight cells was increased (P < 0.05) by capsaicin injected into the arterial supply of the hindlimb. Discharge was unaltered in 19 neurons tested for sensitivity to nonnoxious (40 degrees C) and noxious (47 degrees C) heating of the hindlimb skin. In contrast, lightly stroking the skin elicited discharge in 2 of 14 cells, whereas noxious pinching increased activity in 4 other cells. Rhythmic (1- to 3-s) muscle contraction (MC) increased (P < 0.05) discharge in >60% of neurons tested (11 of 18). Static (10- to 30-s) MC significantly (P < 0.05) increased discharge in four cells, two of which were also responsive to rhythmic MC. Rhythmicand sustained muscle stretch increased discharge (P < 0.05) in three of eight neurons tested. These data indicate that nucleus tractus solitarius neurons receive input from low- and high-threshold cutaneous mechanoreceptors,respond to capsaicin delivered into the hindlimb arterial supply, lack thermal sensitivity, and respond to activation of mechanosensitive as well as metabosensitive endings in skeletal muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:21:54