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Titolo:
Cardiovascular and pulmonary response to oral administration of ATP in rabbits
Autore:
Kichenin, K; Decollogne, S; Angignard, J; Seman, M;
Indirizzi:
Univ Paris 07, Grp Immunol Denis Diderot, F-75251 Paris 05, France Univ Paris 07 Paris France 05 ol Denis Diderot, F-75251 Paris 05, France Inst Rech Preclin, F-92350 Le Plessis Robinson, France Inst Rech Preclin Le Plessis Robinson France F-92350 is Robinson, France
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 88, anno: 2000,
pagine: 1962 - 1968
SICI:
8750-7587(200006)88:6<1962:CAPRTO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESENTERIC ARTERIAL BED; ADENOSINE-TRIPHOSPHATE; BLOOD-FLOW; RAT; PURINES; RECEPTORS; PYRIMIDINES; NUCLEOTIDES; MEMBRANES; A(1);
Keywords:
ATP; oral; vasodilatation; bronchodilatation; arterial partial pressure of oxygen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kichenin, K Univ Paris 07, Grp Immunol Denis Diderot, Hall Biotechnol,Tour54,CP7124,2Pl Jussieu, F-75251 Paris 05, France Univ Paris 07 Hall Biotechnol,Tour 54,CP7124,2 Pl Jussieu Paris France 05
Citazione:
K. Kichenin et al., "Cardiovascular and pulmonary response to oral administration of ATP in rabbits", J APP PHYSL, 88(6), 2000, pp. 1962-1968

Abstract

Extracellular purines such as ATP and adenosine participate in the regulation of cardiovascular and respiratory functions through specific P1 and P2 purine receptors. These properties have mainly been described after intravenous infusion. Experiments reported herein were designed to explore the possible effect of oral ATP administration (3 or 20 mg.kg(-1).day(-1)) on vascular, cardiac, and pulmonary functions in rabbits. Whereas a unique oral dose of ATP has no effect, chronic supplementation during 14 days reduces peripheral vascular resistance, pulmonary resistance, and respiratory frequency and increases arterial PO2. No effect on central blood pressure and heartrate is observed, but an increase of the left ventricular work index is noticed subsequent to the diminution of vascular resistance. Rather similar cardiovascular modifications are observed in rabbits given 20 mg.kg(-1).day(-1) adenosine for 14 days but without variation of respiratory parameters. These original effects of repeated oral treatment with ATP may result from an adaptive metabolic response to nucleoside supplementation that might affect the turnover of extracellular purines leading to P1- and/or P2-receptoractivation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:16:52