Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The effect of endogenous dehydroepiandrosterone sulphate on antibody response to hepatitis B vaccine in neonates
Autore:
Somekh, E; Dagan, R; Hanukoglu, A;
Indirizzi:
Wolfson Med Ctr, Pediat Infect Dis & Immunol Unit, IL-58100 Holon, Israel Wolfson Med Ctr Holon Israel IL-58100 munol Unit, IL-58100 Holon, Israel Wolfson Med Ctr, Dept Pediat, IL-58100 Holon, Israel Wolfson Med Ctr Holon Israel IL-58100 ept Pediat, IL-58100 Holon, Israel Soroka Univ Hosp, Pediat Infect Dis Unit, Beer Sheva, Israel Soroka Univ Hosp Beer Sheva Israel Infect Dis Unit, Beer Sheva, Israel
Titolo Testata:
ISRAEL MEDICAL ASSOCIATION JOURNAL
fascicolo: 3, volume: 2, anno: 2000,
pagine: 200 - 202
SICI:
1565-1088(200003)2:3<200:TEOEDS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE FUNCTION; SULFATE; DHEA; ADJUVANT; ILLNESS;
Keywords:
DHEAS; antibody; neonates; immune response; hepatitis B vaccine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Somekh, E Wolfson Med Ctr, Pediat Infect Dis & Immunol Unit, IL-58100 Holon, Israel Wolfson Med Ctr Holon Israel IL-58100 , IL-58100 Holon, Israel
Citazione:
E. Somekh et al., "The effect of endogenous dehydroepiandrosterone sulphate on antibody response to hepatitis B vaccine in neonates", ISR MED ASS, 2(3), 2000, pp. 200-202

Abstract

Background: DHEAS, the most abundant steroid secreted by the adrenal cortex, is suggested to have an important role in the development of immune reaction by activating T cell function and increasing antibody response, and has been tried as a vaccine adjuvant in elderly people. Objectives: We examined the correlation between endogenous DHEAS and antibody response in the neonatal period by comparing the serum DHEAS levels with the amount of antibody response against hepatitis B vaccination in neonates. Methods: Vaccine was administered to 12 healthy infants within 24 hours ofbirth (day 0), and blood Specimens were obtained on days 0 and 30 for determination of anti-hepatitis B surface antibody concentration and DHEAS levels. Results: DHEAS levels varied widely (range 0.38-3.70 mu g/ml, mean+/-SD 2.14+/-0.98). While we could identify two groups of patients - those with high DHEAS levels (2.90+/-0.56) and those with lower levels (1.30+/-3.56) - here was no correlation between DHEAS levels and the antibody response to hepatitis B vaccine (r=-0.05). Conclusions: In neonates, antibody response to hepatitis B vaccine does not correlate with DHEAS serum levels. These results do not support the usageof DHEAS as a vaccine adjuvant in neonates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:41:28