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Titolo:
Autologous chondrocyte transplantation for reconstruction of isolated joint defects: the Assaf Harofeh experience
Autore:
Robinson, D; Ash, H; Aviezer, D; Agar, G; Halperin, N; Nevo, Z;
Indirizzi:
Assaf Harofeh Med Ctr, Dept Orthoped, IL-70300 Zerifin, Israel Assaf Harofeh Med Ctr Zerifin Israel IL-70300 , IL-70300 Zerifin, Israel CTI Ltd, Kiriat Weizmann, Nes Ziona, Israel CTI Ltd Nes Ziona IsraelCTI Ltd, Kiriat Weizmann, Nes Ziona, Israel Tel Aviv Univ, Sackler Fac Med, Dept Clin Biochem, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 iochem, IL-69978 Tel Aviv, Israel
Titolo Testata:
ISRAEL MEDICAL ASSOCIATION JOURNAL
fascicolo: 4, volume: 2, anno: 2000,
pagine: 290 - 295
SICI:
1565-1088(200004)2:4<290:ACTFRO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTICULAR-CARTILAGE DEFECTS; COLLAGEN GEL; SURFACES; REPAIR; KNEE;
Keywords:
chondrocyte transplantation; joint cartilage; articular surface; bioengineering; cartilage repair;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Robinson, D Assaf Harofeh Med Ctr, Dept Orthoped, IL-70300 Zerifin, IsraelAssaf Harofeh Med Ctr Zerifin Israel IL-70300 erifin, Israel
Citazione:
D. Robinson et al., "Autologous chondrocyte transplantation for reconstruction of isolated joint defects: the Assaf Harofeh experience", ISR MED ASS, 2(4), 2000, pp. 290-295

Abstract

Background: Articular cartilage is incapable of undergoing self-repair since chondrocytes lose their mitotic ability as early as the first year of life. Defects in articular cartilage, especially in weight-bearing joints, will predictably deteriorate toward osteoarthritis. No method has been found to prevent this deterioration. Drilling of the subchondral bone can lead tofibrocartilage formation and temporary repair that slowly degrades. Animalexperiments indicate that introducing proliferating chondrocytes such as cultured articular chondrocytes can reliably reconstruct joint defects. Objectives: To describe our clinical experience in culturing and transplanting autologous chondrocytes. Methods: Biopsies were obtained from 10 patients, aged 18-45, undergoing aroutine arthroscopy in which a cartilage defect was identified with indications for cartilage transplantation. The biopsies were further processed toestablish chondrocyte cultures. ACT was performed in 8 of the 10 patients because of persistent symptoms for at least 2 months post-arthroscopy. All patients (6 men and 2 women) had a grade IV cartilage defect in the medial or lateral femoral condyle, and three had a defect in the trochlear region as well. Biopsies were removed from the lateral rim of the superior aspect of the femur, and cells were cultured in a clean room. Following a 2 order of magnitude expansion; cells were implanted under a periosteal flap. Results: The eight patients implanted with autologous cells were followed for 6 months to 5 years (average 1 year). Complaints of giving-way, effusion and joint locking resolved in all patients, and pain as assessed by the visual analogue score was reduced by an average of 50%. Follow-up magnetic resonance imaging studies in all patients revealed that the defects were filled with tissue having similar signal characteristics to cartilage. Conclusions: Chondrocyte implantation is a procedure capable of restoring normal articular cartilage in cases with isolated joint defects. Pain can be predictably reduced, while joint locking and effusion are eliminated. Theeffect on osteoarthritis progression in humans has not yet been elucidated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:49:55