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Titolo:
Alteration of tumor phenotypes of B16 melanoma after genetic remodeling ofthe ganglioside profile
Autore:
Tsurifune, T; Ito, T; Li, XJ; Yamashiro, S; Okada, M; Kanematsu, T; Shiku, H; Furukawa, K;
Indirizzi:
Nagoya Univ, Sch Med, Dept Biochem 2, Showa Ku, Nagoya, Aichi 4660065, Japan Nagoya Univ Nagoya Aichi Japan 4660065 a Ku, Nagoya, Aichi 4660065, Japan Nagasaki Univ, Sch Med, Dept Surg 2, Nagasaki 8528102, Japan Nagasaki Univ Nagasaki Japan 8528102 ept Surg 2, Nagasaki 8528102, Japan Nagasaki Univ, Sch Med, Dept Psychiat, Nagasaki 8528102, Japan Nagasaki Univ Nagasaki Japan 8528102 t Psychiat, Nagasaki 8528102, Japan Mie Univ, Sch Med, Dept Internal Med 2, Tsu, Mie 5148507, Japan Mie Univ Tsu Mie Japan 5148507 pt Internal Med 2, Tsu, Mie 5148507, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 1, volume: 17, anno: 2000,
pagine: 159 - 165
SICI:
1019-6439(200007)17:1<159:AOTPOB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE GENE; MONOCLONAL-ANTIBODY; CELL-ADHESION; EXPRESSION; BIOSYNTHESIS; MEMBRANE; GLYCOSPHINGOLIPIDS; SPECIFICITY; ATTACHMENT; REACTIVITY;
Keywords:
gangliosides; glycosyltransferase; transfection; GM2; melanoma; remodeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Furukawa, K Nagoya Univ, Sch Med, Dept Biochem 2, Showa Ku, 65 Tsurumai, Nagoya, Aichi4660065, Japan Nagoya Univ 65 Tsurumai Nagoya Aichi Japan 4660065 0065, Japan
Citazione:
T. Tsurifune et al., "Alteration of tumor phenotypes of B16 melanoma after genetic remodeling ofthe ganglioside profile", INT J ONCOL, 17(1), 2000, pp. 159-165

Abstract

Gangliosides have been thought to be tumor markers of various neuroectoderm-derived cancers. However, their roles in malignant phenotypes of cancer cells are not well understood. We have performed the remodeling of ganglioside profiles of mouse melanoma B16 (B78 subline) by introducing GM2/GD2 synthase cDNA, and analyzed the phenotypic changes such as cell morphology, growth, adhesion and c-fos gene expression. Although newly expressed GM2 was clearly detected, GM2-positive transfectant cells showed rather reduced growth rates in vivo and in vitro, lower expression levels of c-fos gene and increased levels of cell adhesion to extracellular matrices compared to control cells, These results suggested that GM2 is involved in the regulation ofcell-cell or cell-extracellular matrix interaction, and negatively controlcell proliferation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 02:43:01