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Titolo:
Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues
Autore:
Mori, K; Hasegawa, M; Nishida, M; Toma, H; Fukuda, M; Kubota, T; Nagasue, N; Yamana, H; Chung, KHY; Ikeda, T; Takasaki, K; Oka, M; Kameyama, M; Toi, M; Fujii, H; Kitamura, M; Murai, M; Sasaki, H; Ozono, S; Makuuchi, H; Shimada, Y; Onishi, Y; Aoyagi, S; Mizutani, K; Ogawa, M; Nakao, A; Kinoshita, H; Tono, T; Imamoto, H; Nakashima, Y; Manabe, T;
Indirizzi:
Nippon Roche Res Ctr, Cytostat Grp, Kanagawa, Japan Nippon Roche Res Ctr Kanagawa Japan Ctr, Cytostat Grp, Kanagawa, Japan Tokyo Womens Med Univ, Inst Gastroenterol, Dept Urol, Tokyo, Japan Tokyo Womens Med Univ Tokyo Japan astroenterol, Dept Urol, Tokyo, Japan Tokyo Womens Med Univ, Inst Gastroenterol, Dept Gastrointestinal Surg, Tokyo, Japan Tokyo Womens Med Univ Tokyo Japan t Gastrointestinal Surg, Tokyo, Japan Yokosuka Kyosai Hosp, Dept Urol, Kanagawa, Japan Yokosuka Kyosai Hosp Kanagawa Japan ai Hosp, Dept Urol, Kanagawa, Japan Keio Univ, Sch Med, Dept Surg, Tokyo 108, Japan Keio Univ Tokyo Japan 108 eio Univ, Sch Med, Dept Surg, Tokyo 108, Japan Keio Univ, Sch Med, Dept Urol, Tokyo 108, Japan Keio Univ Tokyo Japan 108 eio Univ, Sch Med, Dept Urol, Tokyo 108, Japan Shimane Med Univ, Dept Surg 2, Izumo, Shimane 693, Japan Shimane Med UnivIzumo Shimane Japan 693 urg 2, Izumo, Shimane 693, Japan Kurume Univ, Sch Med, Dept Surg, Kurume, Fukuoka, Japan Kurume Univ Kurume Fukuoka Japan Med, Dept Surg, Kurume, Fukuoka, Japan Osaka City Univ, Dept Surg 1, Osaka, Japan Osaka City Univ Osaka JapanOsaka City Univ, Dept Surg 1, Osaka, Japan Osaka City Univ, Dept Surg 2, Osaka, Japan Osaka City Univ Osaka JapanOsaka City Univ, Dept Surg 2, Osaka, Japan Yamaguchi Univ, Sch Med, Dept Surg 2, Yamaguchi, Japan Yamaguchi Univ Yamaguchi Japan , Sch Med, Dept Surg 2, Yamaguchi, Japan Osaka Med Ctr Canc & Cardiovasc Dis, Dept Surg, Osaka, Japan Osaka Med CtrCanc & Cardiovasc Dis Osaka Japan Dept Surg, Osaka, Japan Tokyo Metropolitan Komagome Hosp, Dept Surg, Tokyo, Japan Tokyo Metropolitan Komagome Hosp Tokyo Japan p, Dept Surg, Tokyo, Japan Tokyo Metropolitan Komagome Hosp, Dept Obstet & Gynecol, Tokyo, Japan Tokyo Metropolitan Komagome Hosp Tokyo Japan et & Gynecol, Tokyo, Japan Yamanashi Med Univ, Dept Surg 1, Yamanashi, Japan Yamanashi Med Univ Yamanashi Japan Univ, Dept Surg 1, Yamanashi, Japan Jikei Univ, Sch Med, Dept Obstet & Gynecol, Tokyo, Japan Jikei Univ Tokyo Japan iv, Sch Med, Dept Obstet & Gynecol, Tokyo, Japan Nara Med Univ, Dept Urol, Nara, Japan Nara Med Univ Nara JapanNara Med Univ, Dept Urol, Nara, Japan Tokai Univ, Sch Med, Dept Surg, Hiratsuka, Kanagawa 25912, Japan Tokai Univ Hiratsuka Kanagawa Japan 25912 iratsuka, Kanagawa 25912, Japan Kyoto Univ, Surg Basic Sci Grad Sch Med, Dept Surg 1, Kyoto, Japan Kyoto Univ Kyoto Japan asic Sci Grad Sch Med, Dept Surg 1, Kyoto, Japan Kagoshima City Hosp, Dept Obstet & Gynecol, Kagoshima, Japan Kagoshima City Hosp Kagoshima Japan Obstet & Gynecol, Kagoshima, Japan Kumamoto Univ, Sch Med, Dept Surg 2, Kumamoto 860, Japan Kumamoto Univ Kumamoto Japan 860 h Med, Dept Surg 2, Kumamoto 860, Japan Nagoya Univ, Sch Med, Dept Surg 2, Nagoya, Aichi, Japan Nagoya Univ Nagoya Aichi Japan ch Med, Dept Surg 2, Nagoya, Aichi, Japan Kansai Rosai Hosp, Dept Surg, Amagasaki, Hyogo, Japan Kansai Rosai Hosp Amagasaki Hyogo Japan pt Surg, Amagasaki, Hyogo, Japan Osaka Red Cross Hosp, Dept Surg, Osaka, Japan Osaka Red Cross Hosp OsakaJapan ed Cross Hosp, Dept Surg, Osaka, Japan Nagoya City Univ, Sch Med, Dept Surg 1, Nagoya, Aichi, Japan Nagoya City Univ Nagoya Aichi Japan d, Dept Surg 1, Nagoya, Aichi, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 1, volume: 17, anno: 2000,
pagine: 33 - 38
SICI:
1019-6439(200007)17:1<33:ELOTPA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORAL FLUOROPYRIMIDINE CARBAMATE; HUMAN CANCER XENOGRAFTS; 5-FLUOROURACIL; CAPECITABINE;
Keywords:
ELISA; dThdPasc/DPD ratio; cancer profiling therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Mori, K Nippon Roche Res Ctr, Cytostat Grp, 200 Kajiwara, Kanagawa, Japan Nippon Roche Res Ctr 200 Kajiwara Kanagawa Japan Kanagawa, Japan
Citazione:
K. Mori et al., "Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues", INT J ONCOL, 17(1), 2000, pp. 33-38

Abstract

Thymidine phosphorylase (dThdPase) is the rate-limiting enzyme that metabolizes 5'-deoxy-5-fluorouridine (5'-dFUrd, doxifluridine), an intermediate metabolite of capecitabine, to the active drug 5-fluorouracil (5-FUra), while dihydropyrimidine dehydrogenase (DPD) catabolizes 5-FUra to an inactive molecule. The susceptibility of tumors to fluoropyrimidines is reported to correlate with tumor levels of these enzymes. To obtain some insight into the tumor types susceptible to fluoropyrimidine therapy, we measured expression levels of these two enzymes in various types of human cancer tissues (241 tissue samples) by the ELISA methods. DPD exists in all the cancer types studied, such as bladder, breast, cervical, colorectal, esophageal, gastric, hepatic, pancreatic, prostate, and renal cancers. Among them, the cervical, hepatic, pancreatic, esophageal, and breast cancer tissues expressed high levels of DPD (median >70 U/mg protein), while high concentrations of thedThdPase were expressed in esophageal, cervical, breast, and pancreatic cancers and hepatoma (median >150 U/mg protein). The dThdPase/DPD ratio, which was reported to correlate with the susceptibility of human cancer xenografts to capecitabine, was high in esophageal, renal, breast, colorectal, andgastric cancers (median ratio of >1.5). In any of these three parameters. the inter-patient DPD variability for each cancer type was much larger thanthe DPD variability among cancer types; highest/lowest ratios for dThdPase, DPD, and dThdPase/DPD were 10-321, 7-513, and 2-293, respectively. These results indicate that measurements of the three parameters, DPD, dThdPase acid dThdPase/DPD, would be useful criteria for selecting cancer patients suitable for fluoropyrimidine therapy rather than for selecting cancer types.

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Documento generato il 01/12/20 alle ore 16:45:05