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Titolo:
Apolipoprotein E epsilon 4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with Pick- or microvacuolar-type histology
Autore:
Pickering-Brown, SM; Owen, F; Isaacs, A; Snowden, J; Varma, A; Neary, D; Furlong, R; Daniel, SE; Cairns, NJ; Mann, DM;
Indirizzi:
Univ Manchester, Dept Med, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England Univ Manchester, Sch Biol Sci, Div Neurosci, Manchester, Lancs, England Univ Manchester Manchester Lancs England sci, Manchester, Lancs, England Royal Infirm, Dept Neurol, Manchester, Lancs, England Royal Infirm Manchester Lancs England Neurol, Manchester, Lancs, England Univ Cambridge, Dept Mol Biol, Cambridge CB2 1TN, England Univ Cambridge Cambridge England CB2 1TN iol, Cambridge CB2 1TN, England Inst Neurol, Dept Neuropathol, London WC1N 3BG, England Inst Neurol London England WC1N 3BG europathol, London WC1N 3BG, England Inst Psychiat, Dept Neuropathol, London SE5 8AF, England Inst Psychiat London England SE5 8AF europathol, London SE5 8AF, England
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 2, volume: 163, anno: 2000,
pagine: 452 - 456
SICI:
0014-4886(200006)163:2<452:AEE4AH>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-SYSTEM TAUOPATHY; PONTO-NIGRAL DEGENERATION; NEURODEGENERATIVE DISORDERS; ALZHEIMERS-DISEASE; PRESENILE-DEMENTIA; LOBAR ATROPHY; DISINHIBITION-DEMENTIA; E GENOTYPE; TAU-GENE; CHROMOSOME-17;
Keywords:
frontotemporal dementia; motor neurone disease dementia; progressive supranuclear palsy; corticobasal degeneration; Apolipoprotein E gene; epsilon 4 allele;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Mann, DM Univ Manchester, Dept Med, Oxford Rd, Manchester M13 9PT, Lancs, England Univ Manchester Oxford Rd Manchester Lancs England M13 9PT ngland
Citazione:
S.M. Pickering-Brown et al., "Apolipoprotein E epsilon 4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with Pick- or microvacuolar-type histology", EXP NEUROL, 163(2), 2000, pp. 452-456

Abstract

Frontotemporal dementia (FTD) is the second most common cause of preseniledementia. Here we have investigated the frequency of the epsilon 4 allele of the Apolipoprotein (APOE) gene in FTD and in other non-Alzheimer forms of dementia related to FTD such as Motor Neurone disease dementia, semantic dementia, progressive aphasia, progressive supranuclear palsy, and corticobasal degeneration. In none of these diagnostic groups did we find a significant increase in the APOE epsilon 4 allelic frequency, compared to population values. Neither did me observe any affects of the epsilon 4 allele upon age at onset or duration of disease. Ne conclude therefore that polymorphicvariations in the APOE gene do not modulate either the occurrence or progression of these non-Alzheimer forms of dementia. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 03:09:05