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Titolo:
Quinolinic acid released from polymeric brain implants causes behavioral and neuroanatomical alterations in a rodent model of Huntington's disease
Autore:
Haik, KL; Shear, DA; Schroeder, U; Sabel, BA; Dunbar, GL;
Indirizzi:
Cent Michigan Univ, Dept Psychol, Brain Res Lab, Mt Pleasant, MI 48859 USACent Michigan Univ Mt Pleasant MI USA 48859 ab, Mt Pleasant, MI 48859 USA Otto von Guericke Univ, Inst Med Psychol, Fac Med, D-39120 Magdeburg, Germany Otto von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 2, volume: 163, anno: 2000,
pagine: 430 - 439
SICI:
0014-4886(200006)163:2<430:QARFPB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRASTRIATAL INJECTIONS; KYNURENIC ACID; RAT STRIATUM; NEURONS; DELIVERY; LESIONS; MATRIX; SOMATOSTATIN; CARRIERS; CORTEX;
Keywords:
neurodegeneration; Huntington's disease; quinolinic acid; ethylene vinylacetate polymer; motor performance; spatial learning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Haik, KL Cent Michigan Univ, Dept Psychol, Brain Res Lab, Mt Pleasant, MI 48859 USA Cent Michigan Univ Mt Pleasant MI USA 48859 easant, MI 48859 USA
Citazione:
K.L. Haik et al., "Quinolinic acid released from polymeric brain implants causes behavioral and neuroanatomical alterations in a rodent model of Huntington's disease", EXP NEUROL, 163(2), 2000, pp. 430-439

Abstract

Quinolinic acid (QA) is an N-methyl-D-aspartate agonist that has been shown to produce neurotoxic effects that mimic certain neurodegenerative diseases when administered to laboratory animals. Intrastriatal injections of QA in rats have been used extensively to produce some of the neuropathologicaland behavioral deficits that are analogous to Huntington's disease (HD). However, acute intrastriatal injections of QA produce symptoms that are not analogous to the progressive nature of HD. Thus far, models using chronic administration of QA that produce HD-like behavioral and neuroanatomical changes have necessitated the use of a relatively bulky and fragile microdialytic pump apparatus. The present study tested an alternative way of chronically administering QA. Specifically, this study tested whether gradual release of QA from ethylene vinylacetate (EVA) polymers could produce symptoms analogous to HD. Rats received either no implants or bilateral intrastriatalimplants of polymers with or without QA. Subsequent tests for spontaneous motor activity (SMA), grip strength, balance, and learning ability in a radial-arm-water-maze task revealed QA-induced impairments in balance and learning ability, but did not affect grip strength or SMA. Histological analysis revealed QA-induced enlargement of lateral ventricles, striatal atrophy, and striatal neuronal loss, with relative sparing of NADPH-diaphorase-positive neurons. These results suggest that QA released from polymers can produce behavioral and neuropathological profiles analogous to early stages of HD and that EVA polymers offer a useful means of chronically delivering QA in rodent models of neurodegeneration. (C) 2000 Academic Press.

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Documento generato il 06/04/20 alle ore 01:42:07