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Titolo:
Incidence of malignant tumors in patients with acromegaly
Autore:
Higuchi, Y; Saeki, N; Iuchi, T; Uchino, Y; Tatsuno, I; Uchida, D; Tanaka, T; Noguchi, Y; Nakamura, S; Yasuda, T; Yamaura, A; Sunami, K; Oka, Y; Uozumi, A;
Indirizzi:
Chiba Univ, Sch Med, Dept Neurosurg, Chuo Ku, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 Neurosurg, Chuo Ku, Chiba 2608670, Japan Chiba Univ, Dept Internal Med 2, Chuo Ku, Chiba 2608670, Japan Chiba UnivChiba Japan 2608670 rnal Med 2, Chuo Ku, Chiba 2608670, Japan Chiba Univ, Dept Pediat, Chuo Ku, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 ept Pediat, Chuo Ku, Chiba 2608670, Japan Chiba Canc Ctr, Dept Neurosurg, Chuo Ku, Chiba 2600801, Japan Chiba Canc Ctr Chiba Japan 2600801 rosurg, Chuo Ku, Chiba 2600801, Japan Naruto Hosp, Chiba 2891326, Japan Naruto Hosp Chiba Japan 2891326Naruto Hosp, Chiba 2891326, Japan Kawatetsu Chiba Hosp 6, Dept Neurosurg, Chuo Ku, Chiba 2600842, Japan Kawatetsu Chiba Hosp 6 Chiba Japan 2600842 Chuo Ku, Chiba 2600842, Japan Kimitsu Chuo Hosp, Dept Neurosurg, Chiba 2920822, Japan Kimitsu Chuo HospChiba Japan 2920822 pt Neurosurg, Chiba 2920822, Japan Matsudo Municipal Hosp 8, Dept Neurosurg, Matsudo, Chiba 2710064, Japan Matsudo Municipal Hosp 8 Matsudo Chiba Japan 2710064 Chiba 2710064, Japan
Titolo Testata:
ENDOCRINE JOURNAL
, volume: 47, anno: 2000, supplemento:, S
pagine: S57 - S60
SICI:
0918-8959(200003)47:<S57:IOMTIP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROINTESTINAL TUMORS; COLONIC POLYPS; CARCINOMA; NEOPLASIA; CANCER; GROWTH;
Keywords:
acromegaly; cancer incidence; colon cancer; malignant tumors; thyroid cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Higuchi, Y Chiba Univ, Sch Med, Dept Neurosurg, Chuo Ku, 1-8-1 Inohana, Chiba 2608670, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 2608670 ba 2608670, Japan
Citazione:
Y. Higuchi et al., "Incidence of malignant tumors in patients with acromegaly", ENDOCR J, 47, 2000, pp. S57-S60

Abstract

Neoplasms may be one of the systemic complications to which we attribute high mortality in acromegaly. The present study was designed to investigate the incidence of malignant tumors in patients with acromegaly in the Japanese population. In this report, 44 patients (25 men and 19 women) with biochemically proven acromegaly were studied retrospectively and had a total 670patient years of the duration of acromegaly. We investigated the incidenceof malignant tumors. There were 5 patients with malignant tumors (5 in men) in this study (11%). Male patients with acromegaly had nearly a 3.5 timeshigher ratio of malignancy than expected and this increased cancer incidence was considered significant (P=0.01). There was no significant increase in cancer incidence of either the total patient population or female patients. The malignant tumors were two thyroid cancers and one colon, one gastricand one bladder cancer. It is of note that the colon cancer of one patientwas diagnosed 2 years after transsphenoidal surgery even though the levelsof serum GH and insulin-like growth factor (IGF-1) were reduced to normal after operation. This preliminary study has suggested that male patients with acromegaly might have a high risk of malignancy and that careful screening for tumors is needed both before and after surgical and medical treatment, even in patients with normalized serum GH and IGF-1 levels.

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Documento generato il 28/11/20 alle ore 04:09:42