Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Akathisia and exacerbation of psychopathology: A preliminary report
Autore:
Duncan, EJ; Adler, LA; Stephanides, M; Sanfilipo, M; Angrist, B;
Indirizzi:
Med Ctr, New York Dept Vet Affairs, New York, NY 10010 USA Med Ctr New York NY USA 10010 rk Dept Vet Affairs, New York, NY 10010 USA NYU, Sch Med, Dept Psychiat, New York, NY USA NYU New York NY USANYU, Sch Med, Dept Psychiat, New York, NY USA
Titolo Testata:
CLINICAL NEUROPHARMACOLOGY
fascicolo: 3, volume: 23, anno: 2000,
pagine: 169 - 173
SICI:
0362-5664(200005/06)23:3<169:AAEOPA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC-INDUCED AKATHISIA; PROPRANOLOL;
Keywords:
akathisia; psychopathology; benztropine; propranolol;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Angrist, B Med Ctr, New York Dept Vet Affairs, 423 E 23rd St, New York, NY10010 USA Med Ctr 423 E 23rd St New York NY USA 10010 York, NY 10010 USA
Citazione:
E.J. Duncan et al., "Akathisia and exacerbation of psychopathology: A preliminary report", CLIN NEUROP, 23(3), 2000, pp. 169-173

Abstract

Akathisia has previously been reported to exacerbate psychopathology and to be associated with noncompliance, suicidality, and violence. One previousstudy found brisk decrements in psychopathology after acute treatment of akathisia with intramuscular biperiden. This study assessed changes in akathisia and psychopathology in 19 patients after separate one-day treatments with intramuscular benztropine and oral propranolol. Benztropine and propranolol led to clinically meaningful and statistically significant decrements in ratings of subjective and objective measures of akathisia and in psychopathology scores. Changes in psychopathology correlated significantly with changes in subjective measures of akathisia after benztropine and with subjective and objective measures of akathisia after propranolol. Changes in akathisia accounted for 9%-42% of the variance in changes in psychopathology. After treatment, statistically significant decrements in Brief psychiatric Rating Scale (BPRS) positive symptoms were noted, and individual items not directly related to the akathisia syndrome, such as conceptual disorganization, hallucinatory behavior, and unusual thought content declined, althoughnot significantly. These findings, taken together with the results of a similar previous study, indicate that the effect of akathisia in exacerbatingpsychopathology is large. If suspected, akathisia should be treated promptly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:47:13