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Titolo:
Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas
Autore:
Hinoshita, E; Uchiumi, T; Taguchi, K; Kinukawa, N; Tsuneyoshi, M; Maehara, Y; Sugimachi, K; Kuwano, M;
Indirizzi:
Kyushu Univ, Fac Med, Grad Sch Med Sci, Dept Med Biochem, Fukuoka 8128582,Japan Kyushu Univ Fukuoka Japan 8128582 ept Med Biochem, Fukuoka 8128582,Japan Kyushu Univ, Fac Med, Grad Sch Med Sci, Dept Anat Pathol, Fukuoka 8128582,Japan Kyushu Univ Fukuoka Japan 8128582 ept Anat Pathol, Fukuoka 8128582,Japan Kyushu Univ, Fac Med, Grad Sch Med Sci, Dept Surg, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Sci, Dept Surg, Fukuoka 8128582, Japan Kyushu Univ, Fac Med, Grad Sch Med Sci, Dept Med Informat Sci, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 d Informat Sci, Fukuoka 8128582, Japan
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 6, volume: 6, anno: 2000,
pagine: 2401 - 2407
SICI:
1078-0432(200006)6:6<2401:IEOAAC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANIC ANION TRANSPORTER; GLUTATHIONE-S-TRANSFERASE; HUMAN GASTRIC-CANCER; CELL LUNG-CANCER; P-GLYCOPROTEIN; PROGNOSTIC-SIGNIFICANCE; NORMAL MUCOSA; CMOAT MRP2; MDR1 GENE; RT-PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Uchiumi, T Kyushu Univ, Fac Med, Grad Sch Med Sci, Dept Med Biochem, 3-1-1Maidashi, Fukuoka 8128582, Japan Kyushu Univ 3-1-1 Maidashi Fukuoka Japan8128582 128582, Japan
Citazione:
E. Hinoshita et al., "Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas", CLIN CANC R, 6(6), 2000, pp. 2401-2407

Abstract

The expression of ATP-binding cassette superfamily transporter genes, suchas P-glycoprotein/multidrug resistance (MDR) 1 and MDR protein (MRP) 1, isoften upregulated in various tumor types and is involved in responses to some anticancer chemotherapeutic agents. Five human MRP subfamily members (MRP2-6) with structural similarities to MRP1 have been identified. The relationships between MRP2-6 mRNA levels and drug resistance are not well understood. Data on 35 patients with colorectal cancer were analyzed. Of the ATP-binding cassette superfamily genes, we asked whether mRNA levels of MDR1, MRP1, MRP2, and MRP3 correlated with drug resistance to anticancer agents. For this analysis, we used quantitative reverse transcription-PCR, and the sensitivity to anticancer agents in surgically resected colon carcinomas wasdetermined using the in vitro succinate dehydrogenase inhibition test. MDR1, MRP1, and MRP3 were highly expressed in normal colorectal mucosa, and the relative mRNA levels of MDR1, MRP1, and MRP3 in cancerous tissues compared with noncancerous tissues were decreased or unchanged. By contrast, MRP2 mRNA expression was low in normal colorectal mucosa and specifically increased in cancer regions compared with noncancerous regions. Of the anticanceragents prescribed for patients with colorectal cancers, including doxorubicin, mitomycin C, cisplatin, 5-fluorouracil, etoposide, and a camptothecin derivative, mRNA expression of MRP2 was significantly associated with resistance to cisplatin. MRP2 may be important for resistance to cisplatin treatment in colorectal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:37:45