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Titolo:
Magnetic resonance-based assessment of global coronary flow and flow reserve and its relation to left ventricular functional parameters - Comparison with positron emission tomography
Autore:
Schwitter, J; DeMarco, T; Kneifel, S; von Schulthess, GK; Jorg, MC; Arheden, H; Ruhm, S; Stumpe, K; Buck, A; Parmley, WW; Luscher, TF; Higgins, CB;
Indirizzi:
Univ Zurich Hosp, Div Cardiol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Nucl Med Sect, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, MR Ctr, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Dept Radiol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Calif San Francisco, Div Cardiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
CIRCULATION
fascicolo: 23, volume: 101, anno: 2000,
pagine: 2696 - 2702
SICI:
0009-7322(20000613)101:23<2696:MRAOGC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL BLOOD-FLOW; ORTHOTOPIC HEART-TRANSPLANTATION; N-13 AMMONIA; QUANTIFICATION; HYPERTROPHY; HYPERTENSION; RECIPIENTS; PRESSURE; STRESS; ARTERY;
Keywords:
magnetic resonance imaging; tomography; circulation; transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Schwitter, J Univ Zurich Hosp, Div Cardiol, Raemistr 100, CH-8091 Zurich, Switzerland Univ Zurich Hosp Raemistr 100 Zurich Switzerland CH-8091 and
Citazione:
J. Schwitter et al., "Magnetic resonance-based assessment of global coronary flow and flow reserve and its relation to left ventricular functional parameters - Comparison with positron emission tomography", CIRCULATION, 101(23), 2000, pp. 2696-2702

Abstract

Background-Measurement of coronary sinus blood now (CSF) by phase-contrastmagnetic resonance (PC-MR) imaging at rest and during hyperemia may allow noninvasive assessment of global coronary hemodynamics. Methods and Results-Sixteen healthy volunteers (age, 22 to 32 years) were examined with MR and PET in random order within 1 to 2 days. At rest and during hyperemia (dipyridamole 0.56 mg/kg), CSF was measured by a cine PC-MR technique (temporal resolution, 40 ms; spatial resolution, 1.25x0.8 mm(2)),and myocardial blood flow (MBF) was measured by [N-13]NH3 PET.PET and MR agreed closely for coronary flow reserve (CFR; mean difference, 2.2 +/- 14.7%; Bland-Altman method). CSF divided by either total left ventricular mass or an estimate of drained myocardium (LVMdrain) correlated highly with PET flow data (r=0.93 and 0.95, respectively) and with measures of oxygen demand, ie, heart rate, afterload-corrected fiber shortening, and peak systolic stress determined by MR (overall correlation coefficients, 0.81 and 0.87, respectively, multivariate analysis). CSF/LVMdrain did not differ significantly from PET-derived MBF (difference, 3.6+/-16.6%). In orthotopic heart transplant recipients (n=9), CFR was reduced and blood supply-demand relationships at rest were shifted toward higher flows (P<0.0001). Conclusions-This integrated MR approach allows comprehensive assessment ofautoregulated and hyperemic coronary flow and is suitable for serial measurements in patients. In transplanted hearts, elevated resting flow is the major cause of reduced CFR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:12:25