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Titolo:
Reduced p21(WAF1/CIP1) protein expression is predominantly related to altered p53 in hepatocellular carcinomas
Autore:
Shi, YZ; Hui, AM; Takayama, T; Li, X; Cui, X; Makuuchi, M;
Indirizzi:
Univ Tokyo, Grad Sch Med, Dept Surg, Hepato Biliary Pancreat Surg Div,Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Surg Div,Bunkyo Ku, Tokyo 1130033, Japan
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 1, volume: 83, anno: 2000,
pagine: 50 - 55
SICI:
0007-0920(200007)83:1<50:RPPEIP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIN-DEPENDENT KINASES; P27(KIP1) EXPRESSION; TUMOR PROGRESSION; BLADDER-CANCER; GROWTH ARREST; P21; INHIBITION; OVEREXPRESSION; MUTATION; CELLS;
Keywords:
p21(WAF1/CIP1); p53; hepatocellular carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Hui, AM Univ Tokyo, Grad Sch Med, Dept Surg, Hepato Biliary Pancreat Surg Div,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1130033 , Tokyo 1130033, Japan
Citazione:
Y.Z. Shi et al., "Reduced p21(WAF1/CIP1) protein expression is predominantly related to altered p53 in hepatocellular carcinomas", BR J CANC, 83(1), 2000, pp. 50-55

Abstract

To investigate the relationship between the expression of p21(WAF1/CIP1) protein and p53 status and the possible role of the two proteins in hepatocellular carcinomas (HCCs), we examined the expression of p21(WAF1/CIP1) and p53 immunohistochemically in 81 tumours from 65 patients with hepatocellular carcinoma. p21(WAF1/CIP1) protein was absent from 59 of 81 tumours (72.8%), and altered p53 expression was found in 43 (53.1%). p21(WAF1/CIP1) expression was significantly associated with p53 status (P = 0.0008); 38 of 59 tumours lacking p21(WAF1/CIP1) protein were accompanied by altered p53 expression. Further analyses showed that p21(WAF1/CIP1) expression was inverselycorrelated with p53 expression in hepatitis C virus (HCV)-related HCCs, but not in HBV-related hepatocellular carcinomas and hepatocellular carcinomas without viral infection. All 11 tumours with intrahepatic metastasis showed altered p21(WAF1/CIP1) Or p53 expression. In contrast, no intrahepatic metastasis was found in any of the 17 tumours without abnormal expression ofeither of the two proteins. These results suggest that: (1) different modes of p21(WAF1/CIP1) regulation are involved in HCCs differing in their hepatitis viral infection status, and p21(WAF1/CIP1) expression appears to be predominantly related to altered p53 in HCV-related HCCs; (2) disruption of the p53-p21(WAF1/CIP1) cell-cycle-regulating pathway may contribute to malignant progression of HCC. (C) 2000 Cancer Research Campaign.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:01:33