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Titolo:
The serotonin transporter in the midbrain of suicide victims with major depression
Autore:
Bligh-Glover, W; Kolli, TN; Shapiro-Kulnane, L; Dilley, GE; Friedman, L; Balraj, E; Rajkowska, G; Stockmeier, CA;
Indirizzi:
Univ Mississippi, Med Ctr, Dept Psychiat & Human Behav, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 Human Behav, Jackson, MS 39216 USA Cuyahoga Cty Coroners Off, Cleveland, OH USA Cuyahoga Cty Coroners Off Cleveland OH USA roners Off, Cleveland, OH USA Case Western Reserve Univ, Univ Hosp Cleveland, Dept Pathol, Cleveland, OH44106 USA Case Western Reserve Univ Cleveland OH USA 44106 , Cleveland, OH44106 USA Case Western Reserve Univ, Dept Psychiat, Program Basic & Clin Neurosci, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 12, volume: 47, anno: 2000,
pagine: 1015 - 1024
SICI:
0006-3223(20000615)47:12<1015:TSTITM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE NUCLEUS; 5-HT UPTAKE SITES; H-3 IMIPRAMINE BINDING; MESSENGER-RNA LEVELS; LOCUS-COERULEUS; AFFECTIVE-DISORDERS; FRONTAL-CORTEX; HUMAN-BRAIN; TYROSINE-HYDROXYLASE; PAROXETINE BINDING;
Keywords:
dorsal raphe nucleus; serotonin transporter; midbrain; major depression; suicide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Stockmeier, CA Univ Mississippi, Med Ctr, Dept Psychiat & Human Behav, 2500 N State St, Jackson, MS 39216 USA Univ Mississippi 2500 N State St Jackson MS USA 39216 6 USA
Citazione:
W. Bligh-Glover et al., "The serotonin transporter in the midbrain of suicide victims with major depression", BIOL PSYCHI, 47(12), 2000, pp. 1015-1024

Abstract

Background: The involvement of serotonin in depression and suicide has been proposed, because major depression is successfully treated by medicationsthat specifically block the serotonin transporter and there is evidence for a decrease in serotonin transporters in major depression mid suicide, Themidbrain dorsal raphe nucleus (DR) has been implicated as a site for diminished serotonergic activity ill that suicide victims with major depression have a significant increase in seroronin-1A autoreceptors in the DR. Methods: [H-3]Paroxetine was used to label the serotonin transporter in the subnuclei of the DR at several rostral-to-caudal levels of the midbrain in ten pairs of suicide victims with major depression and age-matched psychiatrically normal control subjects. Results: There was a significant increase in serotonin transporters in theentire DR progressing from rostral-to-caudal levels in both normal controlsubjects and suicide victims with major depression. At compatable rostral-to-caudal levels, there were no significant differences in [H-3]paroxetine binding between depressed suicide victims mid normal control subjects in either the entire DR or its constituent subnuclei,Conclusions: The pathophysiology of serotonin mechanisms in suicide victims with major depression does not appear to involve alterations in the binding of [H-3]paroxetine to the serotonin transporter in the midbrain DR, BiolPsychiatry 2000;47:1015-1024 (C) 2000 Society of Biological Psychiatry.

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Documento generato il 18/01/20 alle ore 07:20:57