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Titolo:
Drug therapy for urinary incontinence
Autore:
Andersson, KE;
Indirizzi:
Univ Lund Hosp, Dept Clin Pharmacol, S-22815 Lund, Sweden Univ Lund Hosp Lund Sweden S-22815 Clin Pharmacol, S-22815 Lund, Sweden
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL OBSTETRICS & GYNAECOLOGY
fascicolo: 2, volume: 14, anno: 2000,
pagine: 291 - 313
SICI:
1521-6934(200004)14:2<291:DTFUI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVESICAL OXYBUTYNIN CHLORIDE; CONTINUOUS INTRATHECAL BACLOFEN; MUSCARINIC RECEPTOR ANTAGONIST; PRIMARY NOCTURNAL ENURESIS; DOUBLE-BLIND; DETRUSOR HYPERREFLEXIA; OVERACTIVE BLADDER; MULTIPLE-SCLEROSIS; URGE INCONTINENCE; POSTMENOPAUSAL WOMEN;
Keywords:
controlled clinical trials; bladder overactivity; stress incontinence; overflow incontinence; antimuscarinic drugs;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
149
Recensione:
Indirizzi per estratti:
Indirizzo: Andersson, KE Univ Lund Hosp, Dept Clin Pharmacol, S-22815 Lund, Sweden Univ Lund Hosp Lund Sweden S-22815 l, S-22815 Lund, Sweden
Citazione:
K.E. Andersson, "Drug therapy for urinary incontinence", BEST P R CL, 14(2), 2000, pp. 291-313

Abstract

Drugs used for treatment of urinary incontinence may act on the central nervous system (CNS) or peripherally. Few drugs with a defined CNS site of action are available for treatment of urine storage disorders; most of those currently used have a peripheral site of action. To treat bladder overactivity associated with urgency and urge incontinence, antimuscarinic drugs, alpha-adrenoceptor antagonists, beta-adrenoceptor agonists, prostaglandin synthesis inhibitors, and several other agents most often developed for non-urological indications, are employed. Current treatment is based on the use of antimuscarinic drugs, and oxybutynin is, despite a high incidence of side-effects, the gold standard. Pharmacological treatment of stress incontinence has had limited success, and only alpha-adrenoceptor agonists, with and without combination with oestrogens have had a documented effect. New drugs, specifically directed at treatment of urine storage disorders, are desirable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 18:50:20